121例药品不良反应报告分析  

Analysis of 121 Adverse Drug Reaction Reports

作　　者：汤杰[1] 刘东[1] 姜汉英[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院药学部,武汉430030

出　　处：《医药导报》2012年第1期110-113,共4页Herald of Medicine

摘　　要：目的明确药品不良反应(ADR)发生特点,掌握ADR监测及评价情况,规避临床用药风险。方法详细收集华中科技大学同济医学院附属同济医院2008年9月1日～2010年8月31日网络呈报有效的ADR报告表121份,对有关数据进行适当转换后,进行统计分析。结果 121份ADR报告中抗微生物药所占比例最大,其次为抗肿瘤药和循环系统用药;ADR累及器官或系统主要包括全身性损害、皮肤及其附件损害、消化系统损害;其中90例(74.4%)由静脉给药所致;新的、严重的ADR报告共19例,涉及16种药品。结论完善ADR监测报告制度及其分析评价,开展重点监测品种的追踪和信息通报,形成有效信息流,降低临床用药风险。Objective To investigate the characteristics of adverse drug reactions（ADRs） in Tongji hospital, and know well ADR monitoring and assessment for avoiding risk of drug use in clinic. Methods ADR reports in our hospital from September 1, 2008 to August 31,2010 were downloaded from the national and municipal ADR monitoring network. The related data were converted and analyzed statistically. Results Among the 121 ADR cases of medication, antimicrobial agents ranked firstly and followed by the antitumor agents and drugs on circulation system. The main ADRs involved systemic disorders, skin and its appendage damages, and digestive system disorders. Ninety ADR cases （74.4%） were induced by intravenous drip. There were 19 new and serious ADR reports, which related to 16 kinds of medicines. Conclusion It should be paid more attention to establishing high-level ADR monitoring system, carrying out the analysis, tracking high risk medicines, expanding safe research and promulgating precaution to deminish the drug risk.

关 键 词：药品不良反应 分析 药物警戒 

分 类 号：R969.3[医药卫生—药理学]