脑梗塞患者血清中细胞质胸苷激酶1的检测及临床意义  

Study on Serum Concentration and Clinical Significance of Cytosolic Thymidine Kinase 1 in Patients with Cerebral Embolism

作　　者：周桓[1] 陈敏[1] 樊黎[1] 吴晓立[1] 

机构地区：[1]江苏省无锡市第四人民医院检验科,214062

出　　处：《临床输血与检验》2012年第1期37-39,共3页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的检测脑梗塞患者血清细胞质胸苷激酶1(TK1)浓度的变化,初步探讨其临床意义。方法采用免疫印迹增强发光法检测117例脑梗塞患者、60例健康人血清TK1浓度。结果脑梗塞患者血清TK1浓度为1.48±0.13,显著高于健康对照组(0.43±0.10,P<0.01);36.36%(24/66)的脑梗塞新发患者血清TK1高于正常值2.0,平均值为1.99±0.14,显著高于陈旧性脑梗塞患者(0.98±0.05,P<0.01);脑梗塞新发患者血清TK1浓度与脑梗塞发生后检测时间具有相关性。结论新发脑梗塞患者血清TK1浓度显著增高,可能与脑梗塞后组织修复以及血脑屏障的损伤有关。Objective To study the concentration and clinical significance of cytosolic thymidine kinase 1 in patients with cerebral embolism.Method A chemiluminescent dot blot assay was employed to determine the serum concentration of patients with cerebral embolism or health donors.Results The serum concentration of TK1 in patients with cerebral embolism(1.48±0.13) was significantly higher than that in health donors(0.43±0.1,P<0.01).The serum concentration of TK1 was higher than 2.0 in 36.36%(24/36) patients with new developed cerebral embolism.The mean value was 1.99±0.14,which was significantly higher than that in patients with old developed cerebral embolism(0.98±0.05,P<0.01).It demonstrated that serum concentration of TK1 correlated with the time after cerebral embolism occurrence.Conclusion The increase of serum concentration of TK1 in patients with new developed cerebral embolism may correlate to the repair of train tissue and the damage of blood-brain barrier.And it may also provide a novel marker for the prognosis of patients with cerebral embolism.

关 键 词：细胞质胸苷激酶 脑梗塞 临床意义 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R446.11[医药卫生—临床医学]