HIV感染者CD4+T淋巴细胞计数与牙龈出血指数的关系  

The correlation of CD4+ T lymphocyte count and gingival bleeding index in HIV-positive patients

作　　者：王璇[1] 刘静明[1] 贾洪诚[2] 付茜[2] 李晓光[2] 柳月红[2] 杨昆[2] 

机构地区：[1]首都医科大学附属北京同仁医院口腔科,100730 [2]首都医科大学附属北京地坛医院口腔科

出　　处：《北京口腔医学》2011年第6期326-328,共3页Beijing Journal of Stomatology

摘　　要：目的初步探讨HIV阳性患者CD4+T淋巴细胞计数与牙龈出血指数的关系。方法随机选择符合纳入标准的受试者79名。检查受试者菌斑指数、出血指数和血液CD4+T淋巴细胞计数。结果 CD4+T淋巴细胞计数<200个/mm^3者中,54.05%出血指数为1～2;200～500个/mm^3者中,57.58%出血指数为2～4;>500个/mm^3者中,55.56%出血指数为0～1。总体来看,CD4+T淋巴细胞计数与HIV感染者牙龈出血指数无相关关系(P>0.05);CD4+T淋巴细胞计数分层后,并控制菌斑指数进行偏相关分析,CD4+T淋巴细胞计数<200个/mm^3和200～500个/mm^3者偏相关系数分别0.612(P=0.000)、0.353(P=0.048),CD4+T淋巴细胞计数和出血指数有相关性,2组出血指数分别是1.410±0.791和1.904±1.201,差异有显著性(P<0.05)。结论 CD4+T淋巴细胞计数<500个/mm^3的HIV感染者的牙龈出血指数和CD4+T淋巴细胞计数有相关性,且中度免疫抑制者牙龈出血指数高于重度免疫抑制者。而CD4+T淋巴细胞计数>500个/mm^3的HIV感染者的牙龈出血指数和CD4+T淋巴细胞计数没有相关性。Objective To investigate the correlation of CD4 ＋ T lymphocyte count and gingival bleeding index in HIV-positive patients.Methods Seventy-nine HIV-positive patients were selected according to inclusion criteria.Periodontal examination included plaque index（PLI） and gingival bleeding index（BI）,and CD4 ＋ T lymphocytes were counted.Results The BIs were 1-2 in 54.05%of patients with CD4200cells/mm^3,24 in 57.58%of patients with CD4 between 200-500cells/mm^3,0-1 in 55.56%of patients with500cells /mm^3 respectively.No correlation was found between CD4 cell counts and BI when all patients were evaluated.Positive correlations were observed between CD4 cell counts and BI for the subpopulations with CD4200cells/mm^3（r = 0.612,P = 0.000） and between 200—500 cells/ mm^3（r=0.353,P =0.048）.The BIs in these two subpopulations were 1.410±0.791 and 1.904±1.201 respectively.The difference was statistically significant（P0.05 ）.Conclusion Patients with CD4 cell counts500cells /mm^3 showed positive association between CD4 cell count and BI,and severely immunocompromised HIV-positive patients showed less severe ginginval inflammation than moderate ones.Patients with CD4 cell counts500cells /mm^3 showed no association between CD4 cell count and BI.

关 键 词：CD4+T淋巴细胞计数 出血指数 HIV 菌斑 

分 类 号：R781.41[医药卫生—口腔医学]