RCC组织中KISS-1蛋白的表达变化及意义  

Expression and significance of KISS-1 protein of renal cell carcinoma

作　　者：汪建焜[1,2] 项明峰 习小庆[1] 

机构地区：[1]南昌大学第二附属医院,南昌330006 [2]南昌大学研究生院医学部

出　　处：《山东医药》2011年第46期7-8,共2页Shandong Medical Journal

基　　金：江西省卫生厅科技计划项目(20091127)

摘　　要：目的观察肾细胞癌(RCC)组织中KISS-1蛋白的表达变化,并探讨其临床意义。方法采用免疫组化法检测50例RCC、15例癌旁组织及15例正常肾组织中KISS-1蛋白。结果 RCC组织中的KISS-1蛋白的阳性表达率为32.00%,明显低于癌旁组织的73.00%和正常肾组织的66.67%(P均<0.05);KISS-1蛋白与RCC的临床分期、淋巴结转移及分化程度有关(P均<0.05),KISS-1蛋白阳性表达率与RCC分化程度呈负相关(rs=-0.481,P=0.000)。结论 RCC组织中KISS-1蛋白表达明显下调,其对RCC的发生发展有一定的抑制作用;KISS-1蛋白可能成为预测RCC恶性程度的新的生物学指标。Objective To observe the expression of metastasis suppressor gene KISS-1 in renal cell carcinoma （RCC）, and explore its clinical significance. Method The expressions of KISS-1 protein were detected by the immunohistochemical method in 50 cases of RCC tissue, 15 cases of paracarcinoma tissue and 15 cases of normal renal tissue. Resuits The positive rate of KISS -1 protein in RCC tissue was 32.00%, significantly lower than 73.00% in paracarcinoma tissue and 66.67% in normal renal tissue （ all P 〈 0.05 ） ; the expression of KISS-1 protein was correlated with clinical stage, lymph ,ode metastasis and RCC differentiation in the RCC （ all P 〈 0.05 ） , and the positive rate of KISS-1 protein was negatively correlated with RCC differentiation（r = - 0. 481 , P = 0. 000）. Conclusions The expression of KISS-1 protein is visibly decreased in RCC tissue, and it plays a certain inhibitory role in the occurrence and development of RCC. KISS-1 protein may become a new biological indicators of RCC which predicted the malignant level.

关 键 词：肾肿瘤 肾细胞癌 肿瘤转移抑制基因 KISS-1蛋白 

分 类 号：R737.11[医药卫生—肿瘤]