两种梅毒血清试验对梅毒诊断及疗效的价值分析  

The value analysis of two sera methods on syphilis's diagnosis and treatment

作　　者：勾宗蓉 吕连华 

机构地区：[1]绵阳市人民医院,四川绵阳621000

出　　处：《中外医学研究》2012年第1期49-50,共2页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的 探讨梅毒螺旋体明胶颗粒凝集试验(TPPA)和梅毒血浆反应素快速试验(RPR)检测对梅毒诊断和疗效价值分析。方法 对249例梅毒患者、100例非梅毒患者以及80例正常人进行RPR与TPPA联合检测和分析。结果 249例梅毒患者TPPA和RPR的阳性率分别为100%和75.9%。100例非梅毒患者的TPPA和RPR的阳性率分别为0.0%和4.0%;80例健康体检者的TPPA和RPR的阳性率均为0.0%。梅毒患者与对照组TPPA、RPR的测定结果比较,差异有统计学意义(P<0.05)。结论 TPPA和RPR都是梅毒检测快速有效的方法,但TPPA作为确诊试验特异性和灵敏度均明显要高于RPR,在疗效观察价值上RPR则又明显优于TPPA。Objective To analyse the value of RPR （rapid plasma reagin circle test） and TPPA （treponema pallidum antibody particles agglutinate test） for syphilis diagnosis and treatment. Methods A total of 249 cases of syphilis, 100 cases of non - syphilis and 80 eases of normal with RPR and TPPA joint test and analysis were performed. Results Among the 249 cases of syphilis with the positive rates of the TPPA and RPR were respectively 100% and 75.9%, 100 cases of non - syphilis patients with the positive rates of the TPPA and RPR were respectively 0. 0% and 4. 0% ,80 healthy volunteers with the positive rates of the TPPA and RPR were 0. 0% all. Compare the TPPA and RPR results of syphilis and control, the difference was statistically significant （ P 〈 0. 05 ）. Conclusion Both of TPPA and RPR are fast and efficient ways on syphilis diagnosis, but TPPA as a confirmatory diagnosis test,it＇s specificity and sensitivity is significantly higher than RPR, in turn RPR is significantly better than TPPA on the value of clinical therapeutic effect observation.

关 键 词：梅毒 TPPA RPR 诊断 疗效 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]