含5%硝酸钾牙膏抗牙本质敏感的临床研究  

Efficacy of a dentifrice containing 5% potassium nitrate on dental hypersensitivity

作　　者：庄文捷 曹东[2] 

机构地区：[1]泉州医学高等专科学校附属人民医院口腔科,福建泉州362000 [2]上海交通大学医学院附属第九人民医院·口腔医学院牙体牙髓病科．上海市口腔医学重点实验室。上海200011

出　　处：《上海口腔医学》2011年第6期638-640,共3页Shanghai Journal of Stomatology

基　　金：上海市科学技术委员会资助项目(08DZ2271100);上海市重点学科建设项目(S30206)

摘　　要：目的:评价含5%硝酸钾牙膏减轻牙本质敏感症状的临床效果。方法:根据随机、双盲、平行设计的试验原则,将63名受试者随机分为试验组(含5%硝酸钾牙膏)和对照组(普通牙膏)进行试验,试验周期为4周。采用视觉模拟疼痛评分法(VAS)分别记录基线和4周后受试牙的牙敏感指数。采用SPSS13.0软件包对数据进行非参数检验。结果:使用牙膏4周后,试验组牙本质敏感VAS值显著低于基线(P<0.05)。与对照组相比,试验组使用牙膏前后牙本质敏感VAS记分之差显著高于对照组(P<0.05)。结论:含5%硝酸钾牙膏具有显著的抗牙本质敏感效果,可改善患者的整体舒适度。PURPOSE：To evaluate the efficacy of a dentifrice containing 5% potassium nitrate（test） on dental hypersensitivity compared with the fluoride dentifrice（control） over a 4-week period.METHODS： The study design was a randomized,double-blinded,controlled clinical trial.63 subjects were randomly divided into 2 groups,with 31 were given a 5% potassium nitrate dentifrice（experimental group） and the other 32 given a fluoride dentifrice（control group）.Both groups were instructed to brush their teeth twice a day.An air blast stimulus was used to measure the degree of pain using a VAS scale.The data were analysed by the nonparametric Mann-Whitney U test and Wilcoxon-test with SPSS13.0 software package.RESULTS： The VAS（baseline=68.29±8.263,4-week=31.71±6.378） was significantly reduced over the 4 weeks period in the experimental group（P0.05）.After 4 weeks,VAS in the experimental group was significantly lower than that in the control group（P0.05）.CONCLUSION： The study demonstrates that the dentifrice containing 5% potassium nitrate effectively reduces dental hypersensitivity.Supported by Research Fund of Science and Technology Commission of Shanghai Municipality（08DZ2271100） and Shanghai Leading Academic Discipline Project（S30206）.

关 键 词：临床试验 牙过敏 硝酸钾 牙膏 

分 类 号：R781.2[医药卫生—口腔医学]