血浆生长抑素与血管性痴呆的发病部位及其特点的相关性研究  

Research the correlation of plasma somatostatin and vascular dementia's incidence of disease site and characteristic

作　　者：张华[1] 左军杰[2] 刘顺达[1] 蔡海燕[1] 高永英[1] 杨飞虎[2] 

机构地区：[1]宁夏回族自治区人民医院神经内科,银川750021 [2]宁夏医科大学

出　　处：《中华脑血管病杂志（电子版）》2011年第6期25-28,共4页Chinese Journal of Cerebrovascular Diseases(Electronic Edition)

摘　　要：目的探讨血浆生长抑素(SS)与血管性痴呆(VD)的发病部位、病灶大小、数量及其与痴呆的严重程度的关系。方法选择符合脑血管病诊断标准并经颅脑CT和颅脑MRI确诊的多发性脑梗死患者86例,应用简易精神状态量表(MMSE)和蒙特利尔认知评估量表(MOCA)评定患者认知功能并将其分为观察组(VD组)45例,对照组(非VD组)41例,抽取患者静脉血用放射免疫法检测血浆SS含量。结果 (1)VD组血浆SS含量明显低于非VD组(P<0.05,);VD的严重程度与血浆SS呈正相关(r=0.329,P<0.01);(2)发生于额叶皮层、海马、颞叶皮层、丘脑、纹状体等部位的脑梗死患者血浆SS含量明显降低(P<0.05);(3)脑梗死数量多,体积大者,血浆SS含量越低(P<0.05)。结论 (1)VD患者血浆SS水平降低,其降低程度与痴呆严重程度相一致。(2)血浆SS降低水平与VD患者的脑梗死的发病部位、病灶数量及体积有一定相关性。因此对血浆SS的监测有助于血管性痴呆的早期诊断,亦可作为判断病情轻重的重要依据。Objective To investigate the relationship between plasma somatostatin （SS） and vascular dementia （VD） of the disease＇s site, lesion＇ s size and number and severity of dementia. Methods To select 86 patients with multi-infarct, which meet the diagnostic criteria for cerebrovascular disease and the brain CT and MRI brain diagnosis. Mini-mental state examination application （MMSE） and montreal cognitive assessment scale （MOCA） were adopted to valuate the cognitive function of patients. Then these patients were divided into two groups, 45 patients in the observation group （VD group）, and 41 patients in control group （non-VD group）. The radioimmunoassay （RIA）was carried out to test the contents of SS. Results （ 1 ） The contents of SS in VD group were significantly lower than that in non-VD group （P 〈 0.05 ） ; The severity of the VD with plasma SS were positively correlated （ r = 0. 329, P 〈 0.01 ） ; （2） The patients with cerebral infarction which occurred in the frontal cortex, hippo campus, temporal cortex, thalamus, striatum and other parts. The contents of SS were decreased significantly （ P 〈 0.05 ） ; （3 The more the number of cerebral infarction and the greater the volume are, the lower the contents of SS P 〈 0.05）. Conclusions （ 1 ） The contents of SS were decreased in VD,The degree of reduction was consistent with the severity of dementia. （2） The contents of SS have some correlation with the disease＇ s site, Lesion＇ s volume and number of cerebral infarction in VD. The monitoring of SS is helpful to the early diagnosis of VD, But also can serve as a basis for diagnosis the degree of disease.

关 键 词：生长抑素 多发性 脑梗死 血管性痴呆 

分 类 号：R749.13[医药卫生—神经病学与精神病学]