运动性骨骼肌线粒体生物合成的转录及转录后调节  

Transcriptional and Post-transcriptional Regulation of Exercise-induced Mitochondrial Biogenesis

作　　者：喻伯海[1] 朱立艳[2] 余洲[2] 

机构地区：[1]江苏警官学院警体部,江苏南京210012 [2]解放军理工大学理学院军事系,江苏南京211101

出　　处：《南京体育学院学报（自然科学版）》2011年第6期21-24,共4页Joournal of Nanjing Institute of Physical Education:Natural Science

摘　　要：运动或长期运动可引起线粒体的表型发生改变。运动性骨骼肌线粒体的适应具有高度特异性,取决于训练类型(力量或耐力)以及训练的频率、强度和持续时间。运动诱导线粒体的生物合成是多分子事件相互作用的结果。转录及转录后调节在运动诱导线粒体的生物合成起着重要的作用。运动可促进骨骼肌线粒体的生物合成,减缓由于年龄或不运动引起线粒体功能失调,从而提高工作能力和生活的质量。One of the most dramatic phenotypic alterations in adults occurs in mitochondria in response to exercise or chronic contractile activity.Contractile activity-induced mitochondrial adaptations in muscle are highly specific,and dependent upon the type of exercise（i.e.resistance versus endurance）,as well as its frequency,intensity and duration.Changes in mitochondrial biogenesis produced by exercise are a result of multiple molecular events.The multiple transcriptional and post-transcriptional pathways are operative in exercise-induced mitochondrial biogenesis.In skeletal muscle,exercise can play a significant role in accelerating the rate of mitochondrial biogenesis,which can serve to attenuate the possible mitochondrial dysfunction that arises during aging and conditions of muscle disuse,thereby improving work performance and the quality of life.

关 键 词：耐力训练 线粒体 生物合成 

分 类 号：G804.2[文化科学—运动人体科学]