人脐带间充质干细胞移植治疗晚期外伤性癫痫  

Preliminary Study on Human Umbilical Cord Mesenchymal Stem Cells Transplantation in the Treatment of Late Traumatic Epilepsy

作　　者：张合林[1] 李玉强[1] 田爱民[1] 展如才[1] 

机构地区：[1]济南市第三人民医院神经外科,山东省济南市250101

出　　处：《组织工程与重建外科杂志》2011年第6期310-312,共3页Journal of Tissue Engineering and Reconstructive Surgery

摘　　要：目的探讨人脐带间充质干细胞移植治疗晚期外伤性癫痫的临床价值。方法对31例晚期外伤性癫痫患者进行人脐带间充质干细胞移植,观察临床效果。结果癫痫发作完全消失或仅有先兆者21例,极少发作(≤3次/年)者5例,发作明显改善(减少≥75%)者4例,无明显改善(减少<75%)者1例,满意率83.87%。结论人脐带间充质干细胞移植对治疗外伤性癫痫具有较好的效果。Objective To explore the clinical efficacy of human umbilical cord mesenchymal stem cells transplantation in the treatment of late traumatic epilepsy. Methods Thirty-one patients with late traumatic epilepsy were transplanted with human umbilical cord mesenchymal stem cells and the clinical effect was observed. Results During 18.7 months of followup, 21 patients were found to be completely seizures-free or with only aura （Class Ⅲ ）, 5 patients only had rare seizures （Class 9, less than 3 times a year）. And obvious improvement was achieved in 4 patients （Class Ⅲ, at least 75% seizures reduction）, no significant change was observed in 1 case（ClassⅣ, less than 75% seizures reduction）. The satisfactory rate was 83.87%. Conclusion The human umbilical cord mesenchymal stem cells transplantation in the treatment of late traumatic epilepsy can result in a satisfactory clinical effect.

关 键 词：人脐带间充质干细胞 晚期外伤性癫痫 移植 

分 类 号：R742.1[医药卫生—神经病学与精神病学]