顺铂与氟尿嘧啶联合化疗对腹壁皮瓣的影响  

Effects of Combination Chemotherapy with Cisplatin and 5-fluorouracil on Abdominal Flap in Dogs

作　　者：周晓[1] 王伟[2] 戴捷[1] 陈森林[3] 肖腾飞[1] 汪安兰[2] 李俊军[3] 

机构地区：[1]湖南省肿瘤医院整形外科,湖南省长沙市410013 [2]湖南省肿瘤医院肿瘤内科,湖南省长沙市410013 [3]湖南省肿瘤医院病理科,湖南省长沙市410013

出　　处：《组织工程与重建外科杂志》2011年第6期317-320,共4页Journal of Tissue Engineering and Reconstructive Surgery

基　　金：湖南省卫生厅课题基金(B2005142)

摘　　要：目的观察术前顺铂与氟尿嘧啶诱导化疗对实验犬腹壁皮瓣存活的影响。方法健康成年杂种雄性犬21只．随机分为化疗组、阴性对照组和空白对照组（n=7）。化疗组予以顺铂50mg／m2（Cisplatin．DDP）加氟尿嘧啶150mg／m2（5-fluorouracil，5-Fu）；阴性对照组予以等量生理盐水及葡萄糖注射液；空白对照组不予任何药物。分别于第1、3、5天经腹壁下静脉给予，每21天为一个周期，共2个周期。于第42～49天进行腹壁皮瓣手术。术后每天观察皮瓣变化．术后第30天用坐标贴纸法测量皮瓣存活面积，并将整个带蒂皮瓣取下，对皮瓣及腹壁血管进行病理学分析。结果化疗组5只．阴性对照组6只，空白对照组6只，共计17只实验犬存活。术后2～3d内，各组皮瓣均有不同程度肿胀。术后30d各组皮瓣存活率相近，分别为（89．94±7．25）％、（91．13±6．28）％、（89．43±6．44）％，P=0．910。镜下显示各组表皮及皮下组织生长良好；各组腹壁下静脉和动脉内均未见明显的血栓形成及炎细胞浸润。结论顺铂与氟尿嘧啶联合化疗2周期对腹壁皮瓣的愈合无明显不良影响。Objective To investigate the effects of preoperative chemotherapy with cisplatin and 5-fluorouracil on abdominal flap in dogs. Methods Twenty-one male mongrel dogs were randomly divided into 3 groups （n=7）： chemotherapy group, control group and blank control group. The dogs were treated with cisplatin （DDP, 50 mg/m2） and 5-fluorouracil （5- Fu, 150 mg/m2） in chemotherapy group. Chemotherapeutic drugs were intravenously injected on the 1, 3 5 day. Each cycle went for 21 days, a total of 2 cycles. The dogs only received an injection of same amount of saline and glucose in control group, while nothing in the blank control group. The flap surgery was performed 42-49 days after injection and the changes of the flaps were observed after operation. On the 30th day after operation, the flap survival area was measured by means of coordinate transformations, then the entire flap was removed for pathological analysis. Results A total of 17 dogs survived （5 in chemotherapy group, 6 in control group and 6 in blank control group）. In the 2-3 days post operation, different degrees of swelling was observed in each flap. All flaps survived 30 days after operation. The survival area was similar among chemotherapy group, control group and blank control group （P--0.910）. The epidermis and subcutaneous tissue grew well observed by light microscope. No obvious thrombosis and inflammatory cells were found in the inferior epigastric artery and veins in dogs of three groups. Conclusion Two cycles of preoperative chemotherapy with cisplatin and 5-fluorouracil has no significant influence on the survival area of abdominal flap.

关 键 词：诱导化疗 皮瓣 顺铂 氟尿嘧啶 

分 类 号：R730.53[医药卫生—肿瘤]