健脾化浊降逆方治疗脾胃虚弱型糖尿病胃轻瘫129例临床观察  

Clinical observation of diabetic gastroparesis with weakness of the spleen and stomach treated by a recipe for invigorating spleen and eliminating turbid pathogen for descending adverse qi

作　　者：薛国敏 陈立新 冯燕 刘金涛 吴湘萍 郑非 

机构地区：[1]河北省唐山市丰润区中医院糖尿病科,河北丰润064000 [2]河北省唐山市中医医院内科,河北唐山063000

出　　处：《河北中医》2011年第11期1614-1616,共3页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省中医药管理局2011年度中医药类科研计划课题(编号:2011191)

摘　　要：目的观察健脾化浊降逆方对脾胃虚弱型糖尿病胃轻瘫的临床疗效。方法将300例脾胃虚弱型糖尿病胃轻瘫患者随机分为2组,均予糖尿病基础治疗,同时口服降糖药物或胰岛素控制血糖,治疗组150例采用健脾化浊降逆方口服治疗,对照组150例应用多潘立酮片口服治疗。治疗4周后观察2组临床疗效、治疗前后中医证候积分及胃排空率变化情况。结果治疗组150例,失访21例;对照组150例,失访13例。治疗组总有效率89.92%,对照组总有效率67.15%,2组总有效率比较差异有统计学意义(P<0.05),治疗组临床疗效优于对照组。2组治疗后中医证候积分均较本组治疗前降低(P<0.05),且治疗组降低较对照组明显(P<0.01)。2组治疗后平均胃排空率均较本组治疗前显著增加(P<0.05),2组治疗后平均胃排空率比较差异无统计学意义(P>0.05)。结论健脾化浊降逆方可明显改善糖尿病胃轻瘫脾虚胃弱证型的证候表现,提高胃排空率,未见毒副作用。Objective To observe the clinical effect of a prescription for invigorating spleen and eliminating turbid pathogen for descending adverse qi on diabetic gastroparesis with weakness of the spleen and stomach. Meth- ods 300 cases of diabetic gastroparesis with weakness of the spleen and stomach were randomly divided into two groups. Patients in two groups received conventional diabetes treatment, while oral hypoglycemic drugs or insulin to control blood sugar. Treatment group （ n = 150） received a recipe for invigorating spleen and eliminating turbid pathogen for descending adverse qi. Control group （ n = 150） received Domperidone tablet. The clinical effect and changes of syndrome score of traditional Chinese medicine and gastric emptying rate were observed before and after treatment. Results The total effective rate in treatment group （ 89.14% ） was higher than that in control group （67.15%, P 〈0.05）. Syndrome score of traditional Chinese medicine after treatment were decreased as compared with those before treatment in two groups （ P 〈 0.05）. The decrease of syndrome score of traditional Chinese medi- cine in treatment group was superior to that in control group （ P 〈 0.05 ）. Gastric emptying rate after treatment was increased as compared with that before treatment in two groups （ P 〈 0.05 ）. Conclusion A recipe for invigorating spleen and eliminating turbid pathogen for descending adverse qi can improve symptoms status of diabetic gastropare- sis with weakness of the spleen and stomach, enhance gastric emptying rate and has no adverse effect.

关 键 词：糖尿病并发症 胃疾病 辨证 中药疗法 健脾 和胃降逆 

分 类 号：R573.053.1[医药卫生—消化系统] R573.04[医药卫生—内科学]