二氢杨梅素对小鼠移植性肉瘤S180化疗的增效减毒作用  

Synergy and attenuation of dihydromyricetin on chemotherapy of transplanted S180 mice

作　　者：周防震[1,2] 黄敏[1,3] 张晓元[1] 吴晓英[1] 郭勇[1] 

机构地区：[1]华南理工大学,广东广州510641 [2]湖北民族学院生物科学与技术学院,湖北恩施445000 [3]广州军区机关门诊部,广东广州510080

出　　处：《中国医院药学杂志》2012年第2期107-109,共3页Chinese Journal of Hospital Pharmacy

基　　金：广东省教育部产学研结合项目(编号:2009B090600115)

摘　　要：目的:探讨二氢杨梅素(dihydromyricetin,DMY)联合阿霉素对小鼠移植性肉瘤的抑制效果。方法:建立小鼠移植性肉瘤模型,观察DMY和阿霉素处理后各组小鼠移植瘤大小和体重变化。结果:DMY治疗组具有抑制小鼠移植性肉瘤生长的作用,100 mg.kg-1的DMY治疗组的抑瘤率为48.6%(P<0.05);2 mg.kg-1的阿霉素治疗组的抑瘤率为64.4%,而2 mg.kg-1的阿霉素联合100 mg.kg-1的DMY治疗组的抑瘤率为75.4%(P<0.01)。DMY对阿霉素诱导小鼠血清中乳酸脱氢酶(LDH)和谷草转氨酶(AST)增加有明显的抑制作用(P<0.05)。结论:DMY和阿霉素对小鼠移植性肉瘤生长均有明显的抑制作用;DMY能增加阿霉素的抗肿瘤作用,且能降低阿霉素诱导的心肝毒性。OBJECTIVE To study the antiumor efficiency of dihydromyricetin （DMY） and adriamycin on transplanted sarco ma （S180） in mice. METHODS The model of transplanted S180 was established and the tumor volume and weight were observed and recorded. RESULTS DMY could inhibit the growth of the tumor. The inhibitiory rate was 48. 6G, when 100 nag. kg 1 of DMY was orally given. The inhibitiory rate was 64. 4% when 2 mg·kg^-1 of adriamycin was injected peritoneally, The inhibitory rate increased to 75.4 % （P〈0. 01 ） when 100 mg. kg 1 DMY combined with 2 mg· kg^-1 of adriamycin. DMY could inhibite the enhancement of in the serum CK and aspartate aminotransferase induced by adriamycin. CONCLUSION Both DMY and adriamycin could inhibit the growth of the transplanted S180 in mice. DMY could enhance the anti-tumor effects of adriamyein, and attenuate adriamycin-induced heart and liver toxicity.

关 键 词：二氢杨梅素 阿霉素 荷瘤小鼠 

分 类 号：R730.53[医药卫生—肿瘤]