阳雀花根提取物对小鼠抗运动疲劳能力的影响  

Effects of Caragana sinica on Anti-fatigue in Mice

作　　者：何前松[1] 何峰[2] 冯泳[1] 

机构地区：[1]贵阳中医学院,贵阳550002 [2]贵阳中医学院第一附属医院,贵阳550001

出　　处：《中国实验方剂学杂志》2012年第2期177-180,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：2010年贵阳中医学院院内课题

摘　　要：目的:研究阳雀花根提取物对小鼠抗运动疲劳能力的影响。方法:取昆明种小鼠,随机分为空白对照组(给予等体积蒸馏水)和阳雀花根提取物高、中、低3个剂量组(15,10,5 g.kg-1.d-1),分别灌胃给药,15 d后进行负重游泳实验后处死,观察小鼠负重游泳时间、肝糖原(LG)、乳酸(LA)和尿素氮(BUN)等指标的变化。结果:阳雀花根提取物可明显提高小鼠负重游泳能力,与空白对照组比较,其高、中、低剂量对小鼠负重游泳时间延长率分别是93.24%,109.33%,24.66%;能增加小鼠肝糖原含量,其高、中剂量组糖原恢复率分别为30.33,23.37 mg.(100 g)-1.min-1;能降低血清乳酸和尿素氮含量,减少运动后体内乳酸和尿素氮的生成,并能加速体内乳酸和尿素氮的清除。结论:阳雀花根提取物可明显提高小鼠的耐运动疲劳的能力,具有明显的抗疲劳作用。Objective： This experiment studies the anti-fatigue capability of water extracts from the roots of Caragana sinica in mice.Method： Take Kunming mice,and they are divided into control group and experimental group randomly.The experimental group is divided into three dose groups which are high dose group,medium dose group and low dose group（15,10,5 g·kg-1·d-1）,and the three dose groups are irrigated the stomach with the drug individually;while the control group is given the same volume of distilled water.After 15 consecutive days,all the mice both in the control group and the experimental group are subjected to burden swimming and biochemical index detection.The time of the burden swimming was recorded.Meanwhile,half of the mice both in the control group and in the experimental group are measured about their the contents of blood lactic acid（LA）,blood urea nitrogen（BUN） and liver glycogen（LG） after swimming without rest;while another half are measured after they rest for 30 min.Result： The water extracts from the roots of C.sinica could significantly increase the mice＇s ability of burden swimming,decrease the content of LA and BUN,and accelerate their clearance rate after exercise and increase the reserve and recovery rate of LG.Conclusion： Water extracts from the roots of C.sinica can significantly improve the anti-fatigue effects.

关 键 词：阳雀花根 运动性疲劳 肝糖原 乳酸 尿素氮 

分 类 号：R285.5[医药卫生—中药学]