鼻咽癌调强放疗过程中剂量变化分析及疗效评价  

ANALYSIS AND EFFICACY EVALUATION ON THE IMRT DOSE CHANGES FOR NASOPHARYNGEAL

作　　者：胡江[1] 潘军[1] 骆志国[1] 明帮春[1] 

机构地区：[1]湖北医药学院附属医院十堰市太和医院,十堰442000

出　　处：《现代预防医学》2012年第2期508-509,共2页Modern Preventive Medicine

摘　　要：[目的]探讨鼻咽癌调强放疗过程中剂量变化方案及其疗效评价。[方法]对2009年2月～2010年4月入住某院并经过病理诊断证实鼻咽癌患者72例,随机分为A、B、C3个调强剂量组,每组患者24例,各个组别分别采取不同的调强放疗方案。分别在放疗23次结束时、放疗23次结束后3个月、6个月、12个月时对所有患者的口干程度进行跟踪随访和记录。同时在放疗23次结束后12个月对患者的肿瘤消退情况及12月患者生存率进行统计分析。[结果]A组在多数组织器官中的照射剂量高于其余两组,并且对患者腮腺造成的损伤较大。3个组别在疗效方面差异无统计学意义(P﹥0.05)。[结论]A组治疗方案强度过高,需要改进,而B、C两组的治疗方案差别不明显,均适合在鼻咽癌放疗中应用。[Objective]To investigate the nasopharyngeal IMRT dose changes during the program and its efficacy evaluation.[Methods]From february 2009-April 2010,72 patients were pathology confirmed to be nasopharyngeal carcinoma after were randomly divided into A,B and C three IMRT dose group,24 patients in each group,each group do not take a different,respectively,intensity modulated radiation therapy program.23 at the end of radiotherapy,23 radiotherapy after 3 months,6 months,12 months for all patients were followed-up the extent of dry mouth and records.The end of radiotherapy while 23 patients 12 months after regression of the tumor and patient survival rates in December for statistical analysis.[Results]A group in most tissues and organs in the radiation dose was higher than the other two groups,and the parotid gland of patients with damage caused by the larger.Three groups in efficacy was no significant difference（P﹥0.05）.[Conclusion]A group of high intensity treatment programs need to improve,while B,C groups of the treatment difference was not obvious and it＇s suitable for application in radiotherapy.

关 键 词：鼻咽癌 调强放疗 剂量变化 疗效评价 

分 类 号：R739.63[医药卫生—肿瘤]