氟尿嘧啶植入剂有效性的临床观察  

CLINICAL OBSERVATION ON THE INTRAPERITONEAL INTERSTITIAL IMPLANT WITH SUSTAINED-RELEASE FLUOROURACIL DURING OPERATION

作　　者：叶琳[1] 吴崇杰[1] 胡东[1] 熊功友[1] 

机构地区：[1]江西九江市第一人民医院,九江332000

出　　处：《现代预防医学》2012年第2期518-519,530,共3页Modern Preventive Medicine

摘　　要：[目的]探讨胃肠道肿瘤术中腹腔植入缓释氟尿嘧啶的安全性及疗效。[方法]胃肠道肿瘤患者200例行根治术后,分成术中植入缓释氟尿嘧啶组(治疗组)和对照组(IPHC),观察两组术后伤口愈合情况及有无转移等。[结果]治疗组与对照组的切口感染、化学性腹膜炎、吻合口瘘、肠梗阻及胃排空障碍的发生率无统计学差异。两组术后白细胞计数、ALT和肌酐较术前有明显增高,但两组间比较差异无统计学意义(P﹥0.05)。治疗组的局部复发率低于对照组。随访2、3年的生存率在治疗组和对照组之间差异有统计学意义(P﹤0.05)。[结论]胃肠道肿瘤术中腹腔植入缓释氟尿嘧啶是寻找预防肿瘤局部复发转移的新途径。[Objective]To investigate the safety and effective way to prevent the local recurrence of gastrointestinal cancer after operation.[Methods]Two hundred patients with gastrointestinal cancer were randomly divided into controlled group and sustained-release fluorouracil group.[Results]The difference of side effects and postoperative complications between controlled group and sustained-release fluorouracil group was not obviously.WBC,ALT and Cr were different before and after operation,but the difference was not obviously.Two groups have more significant difference with the local recurrence rate and survival rate.[Conclusion]The way of intraperitoneal interstitial implant with sustained-release fluorouracil during operation for gastrointestinal cancer is a new effective method to prevent postoperative local recurrence of colorectal cancer.

关 键 词：5-氟尿嘧啶 胃肠道肿瘤 缓释剂 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]