生长激素受体在胃癌组织中的表达及其临床意义  

Expression of Growth Hormone Receptor in Human Gastric Cancer Tissue and its clinical significance

作　　者：袁媛[1] 李苏宜[2] 卓士超[1] 宋永谦[1] 

机构地区：[1]东南大学附属徐州医院肿瘤内科,江苏徐州221009 [2]东南大学附属中大医院肿瘤科,江苏南京210009

出　　处：《肠外与肠内营养》2012年第1期46-49,共4页Parenteral & Enteral Nutrition

摘　　要：目的:研究人胃癌组织生长激素受体(GHR)的表达情况及其与肿瘤临床病理特点的关系。方法:回顾性分析100例胃癌病人资料,采用免疫组化法检测组织的GHR表达,分析其与肿瘤分化程度、病理分期、Borrmann分型的关系。同时检测其中14例癌旁正常胃黏膜组织的GHR表达情况,分析正常胃黏膜与肿瘤组织GHR表达的差异。结果:胃癌组织中GHR表达阳性率为55%(55/100),正常组织为85.7%(12/14)。GHR表达与临床分期、组织分化程度显著相关(P<0.01),与Borrmann分型相关(P<0.05)。GHR表达与肿瘤发生部位、性别和年龄均无相关性。结论:胃癌组织中GHR的表达存在差异。Objective： To investigate the expression of growth hormone receptor（GHR）in human gastric cancer tissue.Methods： The GHR was detected in samples of the human gastric cancer（100 cases） by immunohistochemistry technique.In 14 of these cases,data of adjacent normal gastric tissue was similarly analyzed.Results： The GHR expression positive rate was 55%（55/100）in the human gastric cancer tissue and 12/14 in normal tissue samples.There were statistic differences among the gastric cancer tissues of different clinical stage,different differentiation and Borrmann type and different tissue type（P0.05）.There were no statistic differences among the gastric cancer tissues of different site,different gender and different age ranges（P0.05）.Conclusion： GHR expression in gastric cancer is differ.

关 键 词：生长激素受体 胃肿瘤 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤] R733.54[医药卫生—临床医学]