男性泌尿生殖系统淋巴瘤临床病理分析  

Male genitourinary system lymphoma: A clinicopathological analysis

作　　者：张春芳[1] 郭庆[1] 刘冲[1] 马捷[1] 马恒辉[1] 周航波[1] 石群立[1] 

机构地区：[1]南京大学医学院临床学院/南京军区南京总医院病理科,江苏南京210002

出　　处：《中华男科学杂志》2012年第1期52-57,共6页National Journal of Andrology

摘　　要：目的:探讨男性泌尿生殖系统淋巴瘤的临床病理特征和免疫表型。方法:回顾性分析35例男性泌尿生殖系统淋巴瘤的病理形态学和免疫组化标记,结合文献对其临床病理特点进行分析。结果:35例淋巴瘤患者的年龄4～83岁,平均年龄56.5岁,≥50岁者28例(80%)。发生于睾丸者最多,28例(80%),其次是前列腺3例(8.6%),精索、精囊、阴茎和附睾各1例(各2.9%)。组织学类型包括:弥漫性大B细胞淋巴瘤(DLBCL)22例(62.9%)、粘膜相关淋巴组织(MALT)淋巴瘤6例(17.1%)、Burkitt淋巴瘤4例(11.4%)、外周T细胞淋巴瘤2例(5.7%)和浆细胞瘤1例(2.9%)。结论:男性泌尿生殖系统淋巴瘤少见,多发生于中老年人,大多是B细胞淋巴瘤,以DLBCL最常见,其次是MALT淋巴瘤、Burkitt淋巴瘤,T细胞淋巴瘤和浆细胞瘤罕见,男性泌尿生殖系统淋巴瘤的确诊依赖组织病理学,免疫组化标记对明确诊断、分型和鉴别诊断具有肯定价值。Objective： To investigate the clinicopathological features and immunophenotypes of male genitourinary system lymphoma.Methods： We retrospectively studied the histopathological characteristics and immunohistochemical markers of 35 cases of male genitourinary system lymphoma,and reviewed the relevant literature.Results： The 35 patients of male genitourinary system lymphoma were aged from 4 to 83（mean 56.5） years,28（80%） of them ≥50 years.Twenty-eight cases（80%） involved the testis,3（8.6%） the prostate,1（2.9%） the spermatic cord,1 the seminal vesicles,1 the penis and 1 the epididymis.Histologically,22 cases（62.9%） were diffused large B cell lymphoma（DLBCL）,6（17.1%） mucosa associated lymphoid tissue（MALT） lymphoma,4（11.4%） Burkitt lymphoma,2（5.7%） peripheral T cell lymphoma,and 1（2.9%） plasmacytoma.Conclusion： Male genitourinary system lymphomas are rare tumors clinically,which occur more often in the elderly.The majority of them are B cell lymphomas,of which the most common is DLBCL,followed by MALT lymphoma and Burkitt lymphoma.T cell lymphoma and plasmacytoma are rare.The diagnosis of male genitourinary system lymphoma relies on the histopathology,and immunohistochemical markers are of high value for its definite diagnosis,classification and differential diagnosis.

关 键 词：男性生殖系统 肿瘤 淋巴瘤 临床病理学 免疫组化 

分 类 号：R737.2[医药卫生—肿瘤] R604[医药卫生—临床医学]