苯并咪唑水相合成及其抑菌活性研究  

Aqueous Phase Synthesis and Antibacterial Activity of Benzimidazole

作　　者：高涛[1] 阮鹏[1] 黄发军[1] 陈邦焱[1] 肖作安[1] 

机构地区：[1]襄樊学院化学工程与食品科学学院,湖北襄阳441053

出　　处：《广州化工》2012年第1期47-49,共3页GuangZhou Chemical Industry

基　　金：襄樊学院大学生科研基金资助

摘　　要：邻苯二胺与3-甲氧基-4-羟基苯甲醛在水中洁净合成了1-(3-甲氧基-4-羟基苄基)-2(3-甲氧基-4-羟基苯基)苯并咪唑。并合成了其Cu(Ⅱ)、Sn(Ⅱ)、Zn(Ⅱ)三个配合物。利用正交法优化了反应条件,较佳条件为反应温度60℃、反应时间2.0 h、胺醛摩尔比0.3。抑菌活性结果表明0.01 g/L浓度的样品对四种菌种均具有较佳的抑菌活性。1-（3-methoxy,4-hydroxy benzyl）-2-（3-methoxy,4-hydroxy phenyl）-1H-Benzo[d] imidazole was synthesized by the reaction of o-phenylenddiamine with p-methoxybenaldehydein in the water clean.And its three complexes of Cu（Ⅱ）,Sn（Ⅱ）and Zn（Ⅱ） were synthesized.Using orthogonally designed experiment,the reaction conditions were optimized,and better conditions for reaction were temperature 60 ℃,reaction time 2.0 h,and amine aldehyde moore than 0.3.Fungicidal activity test showed that the 0.01 g/L concentration samples of four strains of all had better antibacterial activity.

关 键 词：水相 苯并咪唑 正交实验 抑菌活性 

分 类 号：O625[理学—有机化学]