血清多肿瘤标志物胃癌诊断判别方程的建立及其临床意义  

The establishment and clinical significance of discriminant equation for diagnosis of gastric cancer according to serum multiple tumor markers

作　　者：余国行[1] 卿毅[2] 顾咸庆[2] 廖玲[2] 杨宇馨[2] 王东[2] 

机构地区：[1]北京军区天津疗养院肝胆肿瘤科,天津300381 [2]第三军医大学大坪医院野战外科研究所肿瘤中心,重庆400042

出　　处：《重庆医学》2012年第3期249-251,共3页Chongqing medicine

摘　　要：目的建立多肿瘤标志物C12检测系统诊断胃癌的判别方程以提高多肿瘤标志物C12检测系统诊断胃癌的准确率。方法对135例初治胃癌患者、212例胃部良性疾病患者及6 741名健康体检者的12种常见肿瘤标志物检测结果及临床资料进行回顾性分析,通过SPSS18.0统计软件采用Fisher二分类判别分析建立判别诊断方程,比较12种肿瘤标志物和判别诊断函数对肿瘤诊断的准确率差异。结果成功建立胃癌诊断判别方程,诊断正确率总体为95.0%,在正常组为96.1%,在胃癌组为43.7%,较12种肿瘤标志物单项检测均明显提高(P<0.05)。结论用C12多肿瘤标志物蛋白质芯片检测系统判别方程可提高胃癌诊断的准确率,具有较高灵敏度和特异度,优于单项肿瘤标志物检测,具有一定的临床参考价值。Objective To establish the discriminant equation for diagnosis of gastric cancer according to serum multiple tumor markers, that were detected by C-12 multiple tumor markers protein chip detection system, and raise the diagnostic accuracy of gastric cancer. Methods Link the tumor markers detection results and the clinical information of 135 initial treatment patients of gastric cancer,212 digestive system benign disease patients and 6741 health examinations by retrospective study. To adopt to Fisher discriminatory analysis,the discriminant equation for diagnosis of gastric cancer was estabished by SPSS18. 0, and analyzed the difference of diagnostic accuracy of gastric cancer. Results The discriminant equation for diagnosis of gastric cancer was established successfully. The total diagnostic accuracy was 95.0% （the healthy population control group： 96. 1%; gastric cancer group： 43. 7 %）, and it was raised significantly compare to single tumor marker. Conclusion The discriminant equation for diagnosis of gastric cancer can increase the diagnostic accuracy, which is significantly better than the single serum tumor marker, and are helpful in clinic.

关 键 词：胃肿瘤 诊断 多肿瘤标志物 

分 类 号：R735.2[医药卫生—肿瘤]