基质金属蛋白酶-9基因单核苷酸多态性与冠状动脉血管狭窄的相关性  

Correlation between the matrix metalloproteinase-9 gene single nucleotide polymorphim and coronary artery stenosis degree

作　　者：韩一张 静苏 明郑斌 

机构地区：[1]河北医科大学生物化学与分子生物学教研室,河北石家庄050017

出　　处：《中国老年学杂志》2012年第1期5-6,共2页Chinese Journal of Gerontology

基　　金：国家自然科学基金(90919035,30971457,308712272,30770787);河北省杰出青年基金(C2009001541)

摘　　要：目的研究我国河北省汉族人群基质金属蛋白酶-9(MMP-9)基因单核苷酸多态性-1562C>T与冠心病患者冠状动脉狭窄程度的相关性。方法收集经冠状动脉造影证实的冠心病患者91例和101例正常对照者,采用聚合酶链反应后直接测序的方式检测个体的基因型;比较不同基因型与血管狭窄的关系,并分析基因型与狭窄程度的关系。结果血管狭窄病例组和对照组MMP-9 C1562T C/C,C/T,T/T基因型分布频率无差异;C等位基因频率无显著差异;病例组之间各基因型和等位基因频率无显著性差异。结论 C1562T多态可能与冠心病的发生无关。Objective To investigate the correlation between the matrix metalloproteinase-9 （MMP-9） gene single nucleotide polymorphism - 1562C 〉 T and coronary artery stenosis degree in Hebei Han population. Methods Genotypes of the individual were typed in 91 cases of patients with coronary heart disease （CHD） and 101 cases of uormals included subjects by polymerase chain reaction （PCR）. Relationship between the different genotype and vascular stenosis was analyzed. Results There was no difference between vascular stenosis and control groups in genotype distribution frequency of （MMP-9C1562T C/C, C/T, T/T）. There was no difference in C allele frequencies between case and control groups. There was no difference in each genotype and allele frequencies. Conclusions C1562T polymorphism may be unrelated with the occurrence of CHD.

关 键 词：基质金属蛋白酶-9基因 核苷酸多态性 冠状动脉狭窄 

分 类 号：R394.5[医药卫生—医学遗传学]