儿童及青少年肾细胞癌预后的荟萃分析研究  

The prognosis of juvenile renal cell carcinomas： a meta-analysis of the literature

作　　者：饶秋[1] 官兵[1] 周晓军[1] 

机构地区：[1]南京军区南京总医院病理科,210002

出　　处：《中华小儿外科杂志》2012年第1期31-34,共4页Chinese Journal of Pediatric Surgery

基　　金：江苏省自然科学基金（编号：BK2010463）

摘　　要：目的 本文对儿童及青少年肾细胞癌的预后作进一步研究，利用荟萃分析的方法，进一步探讨儿童及青少年肾细胞癌的生物学行为。方法利用多种检索策略获得关于儿童及青少年肾细胞癌预后的相关研究。对纳入文献进行Jadad质量分级。提取研究中数据，对总生存率、无病生存率和病理分期进行荟萃分析。所用软件采用RevMan5．0，共4个研究纳入荟萃分析。结果TFE3阳性。肾细胞癌比TFE3阴性肾细胞癌具有更差的总生存率和无病生存率。TFE3阳性肾细胞癌的病理分期要高（Ⅲ／Ⅳ期）于TFE3阴性肾细胞癌。合并效应量分别为4．59（95％CI：1．46～14．42）、5．79（95％CI：1．85～18．16）和5．89（95％CI：2．23～15．52）。同时该结果也被生存曲线所验证。结论TFE3阳性肾细胞癌的预后要差于TFE3阴性肾细胞癌。Objective To define the biological features of juvenile renal cell carcinomas （RCCs） in children and adolescents by systematic review and meta-analysis. Methods Eligible studies were identified through multiple search strategies. Studies were assessed for quality using the Jadad quality scale. Data were collected and analyzed for overall survival （OS）, disease-free survival （DFS） and stage in patients with TFE3 ＋ juvenile RCCs and TFE3 RCCs. RevMan 5.0 was used for meta-analyses. Resuits A total of 4 studies were included for meta-analysis. Our meta-analysis outcomes showed that TFE3 ＋ pediatric RCCs were significantly associated with a poorer outcomes （OS and DFS） and a higher stage （ Ⅲ/Ⅳ） than TFE3- RCCs Epooled ORs for each group. 4. 59 （95% CI 1.46 - 14. 42） for OS; 5.79 （95% CI 1.85- 18. 16） for DES and 5.89 （95% CI 2.23- 15,52） for stage]This result was also confirmed by OS and DFS curves （P = 0. 005 and P = 0. 001 ）. Conclusions Xpl 1.2 translocation carcinomas appear to have a poorer prognosis than non-Xp1 1.2 translocation carcinomas in children and adolescents.

关 键 词：癌 肾细胞 预后 META分析 

分 类 号：R737.11[医药卫生—肿瘤]