阿托伐他汀对脑梗死后抑郁症状的影响  

Influence of atorvastatin in depressive symptoms in patients with cerebral infarction

作　　者：钟静玫[1] 武绍远[1] 丁里[1] 翟明[1] 孟强[1] 陈辉[1] 郑昆文[1] 赵乃伟[1] 刘达[1] 赵忠[1] 

机构地区：[1]云南省第一人民医院神经内科,云南省卒中筛查中心,昆明650032

出　　处：《中华神经医学杂志》2012年第1期75-78,共4页Chinese Journal of Neuromedicine

摘　　要：目的 探讨阿托伐他汀对脑梗死后抑郁症状有无影响. 方法 回顾性分析云南省第一人民医院神经内科自2009年6月至2010年12月诊治的404例大动脉粥样硬化型脑梗死患者的临床资料,其中阿托伐他汀强化降脂组201例,阿托伐他汀标准降脂组151例,未给降脂组52例；降脂治疗男性组189例,降脂治疗女性组163例.随访观察3个月,评价治疗前后患者汉密尔顿抑郁量表（HAMD）评分并进行统计学分析. 结果 降脂治疗前后患者HAMD评分比较差异无统计学意义（P＞0.05）.强化降脂组、标准降脂组HAMD评分分别与未降脂组比较差异均无统计学意义（P＞0.05）；无抑郁症状、轻中度抑郁症状的脑梗死患者HAMD评分在强化降脂组、标准降脂组与未降脂组间比较差异亦无统计学意义（P.0.05）.降脂治疗后3月女性患者HAMD评分明显高于男性患者,差异有统计学意义（P＜0.05）,但2组间降脂治疗后胆固醇水平、胆同醇降低幅度、阿托伐他汀剂量等比较差异均无统计学意义（P＞0.05）. 结论 阿托伐他汀降脂治疗不会影响脑梗死后抑郁症状.女性脑梗死后抑郁症状与胆固醇水平、胆同醇降低幅度、阿托伐他汀剂量无关.Objective To determine whether atorvastatin will induce depressive symptoms in patients with cerebral infarction. Methods The clinical data of 404 patients with large artery atherosclerotic cerebral infarction, admitted to our hospital from June 2009 to December 2010, were clinically analyzed; these patients were divided into common treatment group （atorvastatin （[7.72±3.01]）mg/d,n=151） and intensive lipid lowering group （atorvastatin [18.58±9.93] mg/d,n=201） and control group （n=52）; 189 males and 163 females accepted lipid-lowering treatment.Hamilton Depression Rating Scale （HAMD） was employed before treatment and 3 months after the treatment and statistical analysis was performed on their scores. Results No significant deviation in scores of HAMD before and after treatment was noted in these patients （P〉0.05）.No significant deviation in scores of HAMD was noted neither between intensive lipid lowering group and control group,nor between common treatment group and control group （P〉0.05）. No significant deviation in HAMD was observed between the treatment groups with mild/no depression symptoms and control group （P〉0.05）.The scores of HAMD in female patients were significantly higher than that in male patients 3 months after treatment （P〈0.05）,but no significant deviations in the level of cholesterol, the lowering degree of cholesterol and the dosage of atorvastatin were observed between female and male patients （P〉0.05）. Conclusion The lipid-lowering treatment with atorvastatin will not induce depressive symptoms in patients with cerebral infarction.The depressive symptoms of female is not related with the level of cholesterol,the lowering degree of cholesterol and the dosage ofatorvastatin.

关 键 词：脑梗死 抑郁症 阿托伐他汀 

分 类 号：R74[医药卫生—神经病学与精神病学]