透明细胞型脑脊膜瘤的临床病理分析  

Clinicopathological analysis of clear cell meningioma

作　　者：武彤彤[1] 杨清绪[1] 李智[2] 蔡方[1] 朱淑玲[1] 张发仁[1] 

机构地区：[1]惠州市中心人民医院病理科,广东惠州516001 [2]中山大学附属第一医院病理科,广东广州510089

出　　处：《南方医科大学学报》2012年第1期131-134,共4页Journal of Southern Medical University

摘　　要：报道2例发生在脊柱和颅内具有幼稚性特征的透明细胞型脑脊膜瘤（CCM）患者,与经典的透明细胞型脑脊膜瘤不同的是2例患者肿瘤都有显示罕见的细胞核异型性、分裂活跃、坏死等原始化现象。肿瘤细胞对上皮膜抗原和Vimtine有免疫反应,MIB-1指数高达40%。对2例患者均实行肿瘤完整切除术。其中男性患者后3个月有局部复发和心室外侧转移。本文对脑脊膜病临床病理特点、诊断及预后进行探讨,并建议术后进行辅助放疗或化疗,并且在随访第1阶段每3~6个月复查磁共振。We present two cases of clear cell meningioma（CCM） in the intracranial and intraspinal region with anaplastic features.On histological examination,both the tumors exhibited unusual anaplastic appearances with nuclear pleomorphism,a high mitotic activity and necrosis,which were different from classical CCMs.The tumor cells were immunoreactive to epithelial membrane antigen（EMA） and vimentin with a high MIB-1 index of 40%.Total excision of the tumors was performed in both cases.The male patient was found to have local recurrence and lateral ventricle metastasis 3 months after the total excision.We reviewed the clinicopathological features,disagnosis and prognosis of the disease.We recommend that postoperative adjuvant radiotherapy or chemotherapy be performed after total tumor excision,and MRI scan every 3-6 months is mandatory during the initial follow-up period.

关 键 词：透明细胞型脑脊膜瘤 幼稚化 复发 

分 类 号：R739.45[医药卫生—肿瘤]