肝细胞肝癌β-catenin的表达与临床病理特征的关系  

Relationships between expressions of β-catenin and the clinicopathological features in human hepatocellular carcinomas

作　　者：徐兵[1] 靳文剑[1] 罗庆丰[1] 洪道显[1] 邱宇安[1] 汪凌玲[1] 

机构地区：[1]江西省肿瘤医院,南昌330029

出　　处：《江西医药》2011年第12期1072-1074,共3页Jiangxi Medical Journal

基　　金：江西省卫生厅课题(编号20073126)

摘　　要：目的探讨肝细胞肝癌β-catenin的表达与HCC患者临床病理特征的关系。方法应用EnVision法检测80例HCC的β-catenin表达情况,并比较与不同临床病理特征之间的关系。结果β-catenin的异位表达为58.75%。β-catenin异位表达与肿瘤分级密切相关(P<0.001);β-catenin的异位表达与肿瘤分期有明显相关(P<0.05);β-catenin的异位表达和肿瘤大小密切相关(P<0.01);HCC中的β-catenin异位表达与肝包膜浸润、淋巴结转移相关(P<0.05);β-catenin的异位表达与卫星灶、血管侵袭、肝内转移、AFP值无统计学意义。结论肝细胞肝癌中β-catenin异位表达常常出现,且与肿瘤发生、发展相关。Objective To investigate the relationships between expressions of β-catenin and the clinicopathological features in human hepatocellular carcinomas.Methods The immunohistochemical staining of β-catenin was performed using EnVision method in 80 specimens from patients with hepatocellular carcinomas.Results Abnormal expression of β-catenin was observed in 58.75%.The abnormal expression of β-catenin were singnificantly correlated with tumor grade（P〈0.001）.Expression of β-catenin was correlated with tumor stage（P〈0.05）.A close correlation was also observed between the abnormal expression of β-catenin and the tumor size（P〈0.01）.The abnormal expression of β-catenin was correlated with lymph node permission,capsular invasion（P〈0.05）.No statistically significant difference was observed between the abnormal expression level of β-catenin and satellite modules,vascular invasion,intrahepatic metastasis and AFP-value.Conclusion The abnormal expression of β-catenin occur frequently in HCC and correlated with the development and progression of hepatocellular carcinomas.

关 键 词：Β-CATENIN 肝细胞肝癌 免疫组化 临床病理特征 

分 类 号：R735.2[医药卫生—肿瘤]