267例浸润性乳腺癌分子亚型的临床病理特点分析  

The Molecular Subtypes and Clinicopathologic Features in 267 Cases with Invasive Breast Cancer

作　　者：王昇[1] 张宁妹[2] 刘奇伦[1] 马薇春[3] 

机构地区：[1]宁夏医科大学总医院肿瘤外科,银川750004 [2]宁夏医科大学总医院病理科,银川750004 [3]银川市第一人民医院肿瘤内科,银川750004

出　　处：《宁夏医科大学学报》2011年第11期1036-1039,共4页Journal of Ningxia Medical University

摘　　要：目的探讨浸润性乳腺癌分子亚型分布及其与临床病理特点的关系。方法选择2009年9月至2011年8月期间明确诊断的女性浸润性乳腺癌病例267例,分析雌激素受体(ER)、孕激素受体(PR)、HER-2的表达水平,以及乳腺癌分子亚型与临床病理特点的关系。结果 267例中52.0%为Luminal A型,16.5%为Luminal B型,Her-2(+)型占15.4%,Triple Negative型占16.1%。各分子亚型乳腺癌患者年龄集中在55岁以下,发病年龄有年轻化趋势。Luminal A型肿瘤分化程度较高,病理TNM分期偏早,晚期病例少,预后良好;Luminal B型组织学分级以Ⅱ级为主,患者中未绝经者比例高。Her-2(+)型乳腺癌肿瘤趋向于低分化,大长径;Triple Negative型乳腺癌患者诊断时原发肿瘤较大,组织学分级高,腋窝淋巴结转移者较多,具有更多不良预后因素。结论浸润性乳腺癌分子亚型分布差异存在统计学意义,并与其临床病理特点密切相关。Objective To explore the relationship between the molecular subtypes and clinicopathologic features in patients with invasive breast cancer.Methods 267 female cases with invasive breast cancer between Sept 2009 and Aug 2011 were included in this study.The expression of estrogen receptor（ER）,progestin receptor（PR） and HER-2 were detected and the relationship between molecular subtypes and clinicopathological features were analyzed.Results The proportions of four molecular subtypes in 267 cases were： luminal A subtype（52.0%）,luminal B subtype（16.5%）,HER-2＋ type（15.4%）,triple negative type（16.1%）.The age of most patients were less than 55 years.The degree of tumor differentiation of luminal A subtype was higher,whose pathologic TNM stage was earlier,having less end-stage patients and better prognosis than those of others.Luminal B subtype was mostly characterized as histological grade Ⅱ and had high proportion of non-menopausal patients.The HER-2＋ type trended to be poorly differentiated and had large diameter.In patients with triple negative type,the size of primary tumor at diagnosis was larger and histological grade was higher,while they had more axillary lymph nodes metastasized and more adverse prognosis factors than those of others.Conclusion The molecular subtype distribution of invasive breast cancer varied,which was closely related with clinicopathologic features.

关 键 词：乳腺癌 分子分型 临床病理 

分 类 号：R737.9[医药卫生—肿瘤]