外周血CK-19评价乳腺癌术后化疗及监控血液微转移  

Evaluation of chemotherapy after surgery and monitoring of breast cancer micrometastases in the peripheral blood with CK-19

作　　者：孙新六[1] 张新丽[2] 周宝琴 

机构地区：[1]山东省泰安市中心医院中心实验室,泰安271000 [2]山东省泰安市中心医院肿瘤内科,泰安271000 [3]山东省青岛市中心血站,青岛266000

出　　处：《安徽医学》2011年第12期2010-2012,共3页Anhui Medical Journal

摘　　要：目的以外周血CK-19为指标评价术后化疗作用及其监控血液微转移意义。方法以120例乳腺癌术后患者为研究对象,巢式RT-PCR检测外周血CK-19 mRNA,比较化疗前后表达差异及CK-19表达与乳腺癌远处转移关系。结果化疗前血液微转移阳性率为23.33%,化疗后为3.33%,差异有统计学意义(P<0.01);CK-19阳性组肿瘤转移率为76.9%,阴性组肿瘤转移率为8.6%,两组差异有统计学意义(P<0.01)。结论术后辅助化疗能降低乳腺癌血液微转移;外周血CK-19能监控乳腺癌血液微转移。Objective With CK-19 in the peripheral blood as indicator to assess the role of postoperative chemotherapy and monitoring of blood micrometastases. Methods 120 breast cancer patients involved in the study, nested RT-PCR was used to detect CK-19 mRNA in peripheral blood, and the expression of CK-19 before and after chemotherapy, and the relationship between CK-19 expression and distant metastasis of breast cancer were compared. Results The rate of micrometastasis was 23.33% before chemotherapy, 3.33% after chemotherapy, and the difference was signifieant（P 〈0.01 ）; the tumor metastasis rate was 76.9% in CK-19 positive group, 8.6% in CK-19 negative group, and the difference was significant （P 〈0.01 ）. Conclusion Postoperative chemotherapy can reduce breast cancer micrometastases in blood. CK-19 in peripheral blood can monitor breast cancer mierometastases.

关 键 词：乳腺癌 血液微转移 CK-19 巢式RT-PCR 

分 类 号：R737.9[医药卫生—肿瘤]