奥沙利铂和羟基喜树碱分别联合5-氟尿嘧啶/亚叶酸钙治疗晚期大肠癌的对照研究  

Comparison of clinical effects between LOHP and HCPT combined with 5-Fu/CF chemotherapy in treatment of advanced colorectal cancer

作　　者：白燕[1] 

机构地区：[1]四川省崇州市人民医院,611230

出　　处：《检验医学与临床》2012年第1期34-35,共2页Laboratory Medicine and Clinic

摘　　要：目的对照研究奥沙利铂(LOHP)和羟基喜树碱(HCPT)分别联合5-氟尿嘧啶/亚叶酸钙(5-Fu/CF)治疗晚期大肠癌的临床效果。方法将符合入选条件的59例晚期大肠癌患者随机分为观察组30例(含LOHP方案)及对照组29例(含HCPT方案),每3周重复,两组均完成3个疗程化疗。对照观察两组的近期疗效及不良反应。结果观察组完全缓解(CR)1例,部分缓解(PR)12例,总有效率(CR+PR)为43.3%;对照组CR 0例,PR 7例,总有效率(CR+PR)为24.1%,差异有统计学意义(P<0.05)。观察组神经毒性及腹泻发生率较高,对照组粒细胞减少发生率较高,但两组恶心、呕吐、脱发等不良反应发生率差异无统计学意义。结论 LOHP联合5-Fu/CF是治疗大肠癌的有效化疗方案,特别适宜晚期大肠癌以及对5-Fu耐药的患者。Objective To compare the clinical effects between oxaliplatin（LOHP） and hydroxycamptothecine（HCPT） combined with 5-Fu/CF chemotherapy in the treatment of advanced colorectal cancerMethods There were 59 cases of advanced colorectal cancer collected according to the research standard in the study.All patients were randomly divided into the observation group（30 cases） treated with LOHP combined 5-Fu/CF and the control group（29 cases） treated with HCPT combined 5-Fu/CF.Both groups were treated with chemotherapy for 3 periods,and the treatment was repeated every 3 weeks.The effect and toxic reactions of the two groups were studied.Results In the observation group,there were 1 case of CR and 12 cases of PR.The total effective rate（CR＋PR） was 43.3%,while in the controlled group no patient reached complete response.The total effective rate（CR＋PR） was 24.1%,P0.05.The main adverse effects in the observation group were nervous toxicity and diarrhea,while the number of granulocyte dropped off in the control group P0.05,but there were no difference between the symptoms of nausea,vomiting and baldness in two groups.Conclusion LOHP combining with 5-Fu/CF chemotherapy is an effective treatment for colorectal cancer,especially for the cases of advanced colorectal cancer and 5-Fu resistance.

关 键 词：晚期大肠癌 化疗 奥沙利铂 羟基喜树碱 

分 类 号：R730.53[医药卫生—肿瘤]