骨髓间充质干细胞与多种支架材料复合效果的系统评价  

Effect of bone marrow mesenchymal stem cells combined with various scaffold materials:A systematic review

作　　者：方志辉[1] 谭金海[1] 曾宪涛[2] 杨永波[1] 李胜[3] 

机构地区：[1]武汉大学中南医院,骨外科,湖北省武汉市430071 [2]湖北医药学院附属太和医院口腔科,湖北省十堰市442000 [3]武汉大学中南医院,泌尿外科,湖北省武汉市430071

出　　处：《中国组织工程研究与临床康复》2011年第49期9249-9253,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:目前骨髓间充质干细胞多和不同生物支架材料复合修复骨缺损,但其效果尚缺乏系统性的评价。目的:系统评价骨髓间充质干细胞与不同骨支架生物材料复合修复骨缺损的效果。方法:检索中国期刊全文数据库(CNKI)、中国生物医学数据库(CBM)、维普中文科技期刊数据库(VIP)及万方数据库1990-01/2011-04有关骨髓间充质干细胞与不同骨支架生物材料复合修复骨缺损的文章,同时手检纳入研究的参考文献。对研究结果定性分析,进行生物材料复合种子细胞的全面总结。结果与结论:从选取的有关生物材料复合骨髓间充质干细胞修复骨缺损的实验中,证实了骨髓间充质干细胞可以和多种生物材料,包括明胶海绵、聚乳酸-聚羟基乙酸共聚物多孔材料、羟基磷灰石、磷酸钙、珊瑚、藻酸盐、壳聚糖聚乳酸、硫酸钙、藻酸钙、左旋聚丙交酯、富血小板血浆有效复合,并可以向成骨细胞分化。提示骨髓间充质干细胞可以促进各种支架材料修复骨缺损的新骨成骨能力。BACKGROUND：Now,bone marrow mesenchymal stem cells（BMSCs） combined with different biological scaffold materials to composite repair bone defect,but the effectiveness is lack of a systematic review.OBJECTIVE：To explore the effect of BMSCs combined with different biological bone scaffold materials on repairing bone defect.METHODS：A computer based online search in CNKI,CBM,VIP and Wanfang to collect the published articles for the randomized controlled trails which using BMSCs as a seed stem cells composite with various scaffold materials from January 1990 to April 2011.Hand searching was also done to obtain any further information about the studies.The quality of the included studies was critically evaluated and data were analyzed.RESULTS AND CONCLUSION：The results showed that the BMSCs could effective compound with various biological materials,including gelatin sponge,poly lactic acid-glycolic acid copolymer porous materials,hydroxyapatite,calcium phosphate,coral,alginate and chitosan poly lactic acid,calcium sulfate,algal acid calcium,L-polylactide and platelet-rich plasma,and could differentiate to osteoblast.It is indicated that BMSCs can promote the ability of various support materials to repair new bone osteogenesis of bone defect.

关 键 词：骨缺损 骨髓间充质干细胞 支架材料 修复 系统评价 

分 类 号：R394.2[医药卫生—医学遗传学]