经颅微电流刺激辅助文拉法辛治疗广泛性焦虑症的疗效观察  

Effectiveness of transcranial electrotherapy stimulation aiding venlafaxine in treatment of generalized anxietydisorder

作　　者：冯少慧[1] 谢琴[1] 姜文娟[1] 李岚[1] 王继中[1] 

机构地区：[1]武汉市精神卫生中心,武汉430022

出　　处：《中华物理医学与康复杂志》2012年第1期38-40,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的探讨经颅微电流刺激（TES）治疗广泛性焦虑症患者的疗效。方法将广泛性焦虑症患者62例分为治疗组32例与对照组30例。治疗组采用TES治疗加文拉法辛治疗，对照组单独用文拉法辛治疗。TES治疗每天1次，疗程2周；文拉法辛每天75-150mg，疗程4周。于治疗前及治疗第1、2、4周末采用汉密尔顿焦虑量表（HAMA）对2组患者进行评定。结果治疗前2组HAMA总评分、精神性焦虑与躯体性焦虑因子评分比较差异均无统计学意义（P〉0．05）；治疗第1周末，2组的HAMA总评分、精神性焦虑与躯体性焦虑因子评分与组内治疗前比较，差异无统计学意义（P〉0．05）；治疗第2，4周末，2组的HAMA总评分、精神性焦虑与躯体性焦虑因子评分与组内治疗前比较，差异均有统计学意义（P〈0．05）；2组在治疗第1、2、4周末HAMA总评分、精神性焦虑因子分与躯体性焦虑因子分总的平均变化差异无统计学意义（P〉0．05）；治疗第1周末，2组HAMA总评分及精神性焦虑因子评分的有效率比较，治疗组优于对照组（P〈0．05），而治疗第2、4周末，2组HAMA总评分及精神性焦虑因子评分的有效率差异无统计学意义（P〉0．05）；治疗第1、2、4周末2组躯体性焦虑因子评分的有效率差异无统计学意义（P〉0．05）。结论TES辅助文拉法辛治疗可较快改善广泛性焦虑症患者的焦虑症状。Objective To investigate the effects of transcranial electrotherapy stimulation （TES）on patients with generalized anxiety disorder （GAD）. Methods A total of 62 patients with GAD were randomly divided into two grotups, the study group （treated with TES and venlafaxine） and the control group （treated with venlafaxine on- ly）. TES was administered 1 time per day for 14 days, while venlafaxine was administered with oral intake of 75-150 mg/d for 4 weeks. The clinical effects were assessed by using Hamilton anxiety scale （HAMA）. Results There was no difference between the two groups in average HAMA total scores, psychic and somatic factor scores before the treatments （P 〉 0.05 ）. The effective rate of study group was significantly higher （ P 〈 0.05 ） at the end of the 1 st week after treatment than, but similar at the end of the 2nd and 4th week after treatment （P 〉 0.05） to that, of con- trol group, with regard to HAMA total score and psychic factor score. With regard to the HAMA somatic factor score, the effective rate of study group was not significantly different from that of control group at the end of the 1 st, 2nd and 4th week after treatment （P 〉 0.05）. Conclusion Transcranial electric stimulation in conjunction with venlafaxine may improve the symptoms of anxiety of patients.

关 键 词：经颅微电流刺激 文拉法辛 广泛性焦虑症 

分 类 号：R749.7[医药卫生—神经病学与精神病学]