基底细胞样型乳腺癌中CAIX的表达及临床意义  

Significance of CAIX expression in basal-like breast carcinomas

作　　者：陈红[1,2] 周炳娟[2] 赵文明[2] 李金梅[2] 张金库[2] 

机构地区：[1]承德医学院研究生部,承德067000 [2]保定市第一中心医院病理科,保定071000

出　　处：《临床与实验病理学杂志》2012年第1期30-32,共3页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨碳酸酐酶IX(carbonic anhydrase IX,CAIX)在基底细胞样型乳腺癌(basal-like breast carcinomas,BLBCs)中的表达,分析其与乳腺癌患者相关临床病理指标的关系。方法应用免疫组化SP法检测CAIX在45例BLBCs、25例非基底细胞样型乳腺癌(non-basal-like breast carcinomas,non-BLBCs)和10例正常乳腺组织中的表达。结果免疫组化检测结果显示,CAIX在BLBCs组织中的阳性表达率明显高于non-BLBCs和正常乳腺组织(P<0.05);BLBCs组织中CAIX的表达与肿瘤直径(P=0.001)、pTNM分期(P=0.014)及淋巴结转移(P=0.006)均呈正相关(P<0.05)。结论 CAIX在BLBCs中高表达,提示其可能参与该型乳腺癌病程进展的重要分子;CAIX的表达与多项临床病理指标、尤其是淋巴结转移密切相关,提示其可作为预测BLBCs淋巴结转移及预后的指标。Purposes To investigate the expression of CAIX and its association with clinicopathologic features in basal-like breast carcinomas （BLBCs）. Methods Immunohistoehemistry was carried out to examine the expression of CAIX in 45 BLBCs,25 nonbasal-like breast carcinomas and 10 normal breast tissues. Results Immunohistochemistry analysis showed that the positive rate of CAIX in BLBCs tissues was significantly higher than that in non-BLBCs and the normal breast tissues（ P 〈 0. 05 ）. The expression of CAIX was positively correlated with lymph nodes metastasis, tumor diameter and pTNM tumor stage （P 〈 O. 05 ）. Conclusion CAIX was up-regulated in BLBCs, and was associated with the progression of BLBCs. CAIX may be a novel molecular marker to predict the prognosis of BLBCs.

关 键 词：乳腺肿瘤 基底细胞样型 CAIX 免疫组化 

分 类 号：R737.9[医药卫生—肿瘤]