肺微瘤型类癌5例报道并文献复习  

Pulmonary carcinoid tumourlets:five cases report and review of literatures

作　　者：何萍[1] 姚广裕[2] 林云恩[1] 莫明聪[1] 刘桂红[1] 顾莹莹[1] 何建行[3] 

机构地区：[1]广州医学院第一附属医院病理科,广州510120 [2]南方医科大学南方医院乳腺中心,广州510515 [3]广州医学院第一附属医院胸外科,广州510120

出　　处：《临床与实验病理学杂志》2012年第1期57-60,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨肺微瘤型类癌(carcinoid tumourlet)的临床病理学特征、免疫表型及病因学。方法对5例肺微瘤型类癌(其中4例伴肺支气管扩张症1,例伴肺腺癌)进行临床病理观察,应用免疫组化Super Vision两步法检测其特异性标记物。结果肺微瘤型类癌常伴发可导致肺部严重纤维化的疾病,亦可见于无基础炎性疾病的肺组织。肿瘤多位于小气道附近,细胞大小较一致,核呈卵圆形及短梭形,未见核分裂及坏死。免疫标记:肿瘤组织CK、EMA、TTF-1呈弱阳性,CgA、Syn、NSE、CD56及VEGF呈强阳性。结论肺微瘤型类癌具有典型类癌的病理特征和免疫表型,可能是典型类癌发生的早期阶段。气道炎症及肺纤维化导致的缺氧并非微瘤型类癌发生的必要条件,可能有其他分子机制参与微瘤型类癌的发生。Purpose To investigate clinicopathologic feature, immunophenotypes and etiology of pulmonary carcinoid tumourlets. Meth. otis The clinicopathologic features of five cases of carcinoid tumourlets were studied. Four of the five cases were associated with pul. monary bronchiectasis and one associated with pulmonary adnocarcinoma. Specific protein markers of the tiny tumors were detected b2 immunohistochemistry. Results Pulmonary carcinoid tumourlets were always accompanied by diseases which result in severe fibrosis o lung, but it can also be detected in lung tissues without underlaying inflammatory diseases. Histologically, carcinoid tumourlets are often located adjacent to small airways. Carcinoid tumourlets are classically composed of a relatively uniform population cells with oval of spindle nuclei. Mitotic activity and necrosis are absent. Intensive positive immunostaining for CgA, Syn, NSE, CD56 and VEGF wer~ detected. Weak positive for CK, EMA and TrF-1 were also observed. Conclusions Pulmonary carcinoid tumourlets resemble to typi. cal carcinoid in pathological feature and immunophenotypes, so it may be the early stage of typical carcinoid. Hypoxia caused by airwa~ inflammation and pulmonary fibrosis is not the necessary etiological factor for carcinoid tumourlets. There may be other molecular mechanisms involved in the genesis of this tumour.

关 键 词：肺肿瘤 类癌 微小瘤 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]