RELN基因rs12705169位点与女性偏执型精神分裂症关联  

Positive association between rs12705169 in RELN and female schizophrenia patients in a Chinese Han population

作　　者：郭伟云[1,2] 张红星[2] 赵晶媛[2] 宋学勤[3] 李文强[2] 郝伟[4] 吕路线[1] 

机构地区：[1]新乡医学院生命科学技术系,新乡453002 [2]河南省精神病医院,河南省生物精神病学重点实验室 [3]郑州大学第一附属医院 [4]中南大学湘雅二医院精神卫生研究所

出　　处：《中国神经精神疾病杂志》2012年第1期18-21,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：国家自然科学基金资助项目(编号:81071090;81071091);卫生部基金项目(编号:200801009);河南省高校科技创新团队支持计划(编号:2008IRTSTHN008);河南省生物精神病学重点实验室开放课题(编号:2009002)

摘　　要：目的以中国汉族偏执型精神分裂症患者为研究对象,重复验证RELN(Reelin)基因单核苷酸多态性与精神分裂症的关联性。方法以美国精神障碍诊断与统计手册第四版为诊断标准(Diagnostic and StatisticalManual of Mental Disorders-Fourth Edition,DSM-Ⅳ)在河南省北部地区收集326例偏执型精神分裂症患者(男女各半),在同一地域招募健康体检者334名(男女各半)作为对照,检测RELN基因rs12705169、rs11764507和rs17157643单核苷酸多态性位点。结果仅发现患者组和对照组之间rs12705169位点的基因型和等位基因频率差异有统计学意义(P<0.01)。按性别分层后进一步分析,rs12705169在女性患者和对照之间基因型和基因频率分布差异具有统计学意义(CC:OR=0.27,95%CI=0.18～0.45;AC:OR=0.43,95%CI=0.29～0.63,P<0.01)。结论RELN基因多态性与中国女性偏执型汉族精神分裂症存在关联,RELN基因可能是精神分裂症的易感基因。Objective To analyze the association between single nucleotide polymorphisms （SNPs）, in RELN gene and paranoid schizophrenia, and to determine if the RELN gene is a susceptibility gene for schizophrenia in the Han Chinese population. Methods The participants consisted of 326 patients with paranoid schizophrenia （163 males and 163 females） and 334 healthy controls （167 males and 167 females）. All patients were unrelated Han Chinese born and living in the North Henan province. The concurrent diagnoses were made by psychiatrists according to the Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition （DSM-IV） （1994）. Healthy controls were recruited from volunteers with simple nonstructured interview performed by psychiatrists. Three SNPs were selected and genotyped. Genotyping was performed using the Real-time PCR. Genotype and Mlele frequencies were compared between patients and controls to assess the association to schizophrenia. Results A significant association was found between rs12705169 and schizophrenia （P 〈 0.01）. The Allelic and genotypic associations of rs12705169 with schizophrenia remained significant only in females after adjustment for gender （OR = 0.27, 95%CI = 0.18 - 0.45 for CC and OR = 0.43, 95%CI = 0.29 - 0.63 for AC）. Conclusions The present study has revealed a positive asso- ciation between rs12705169 in RELN and female paranoid schizophrenia in the Han Chinese population, indicating that rs12705169 polymorphism of RELN is a risk factor for schizophrenia in chinese females.

关 键 词：精神分裂症 RELN 关联分析 性别 多态性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]