胃食管阀瓣在胃食管反流病中的分布及其与症状的相关性  

Distribution of Gastroesophageal Flap Valve and its Relationship with Symptoms in Gastroesophageal Reflux Disease

作　　者：谢佳平[1] 任晓燕[2] 李复领[2] 赵景润[1] 

机构地区：[1]聊城市人民医院消化内科,252000 [2]聊城市人民医院中心实验室,252000

出　　处：《胃肠病学》2011年第12期717-720,共4页Chinese Journal of Gastroenterology

摘　　要：背景:近年我国胃食管反流病(GERD)的发生率不断升高,胃食管阎瓣(GEFV)分级对评估GERD有重要作用。目的:探讨GEFV在GERD中的分布特征及其与患者症状的关系。方法:选取2010年1～12月聊城市人民医院行胃镜检查发现的343例糜烂性食管炎(EE)、483例非糜烂性反流病(NERD)和99例Barrett食管(BE)患者,记录GEFV的Hill分级,采用GERD症状评定量表(GSAS)记录症状频率、严重度评分。比较GERD各型中GEFV的分布及其与症状频率、严重度评分的关系。结果:异常GEV多见于男性、高龄、超重和食管裂孔疝患者。随着EE的Los Angeles分级增加,异常GEV的发生率增加(P=0.002);GEFV分级在EE、NERD和BE组间的分布无明显差异(P=0.612):与正常GEFV组相比,异常GEFV组GERD的症状频率评分明显增高(P<0.05),而症状严重度评分无明显差异(P>0.05)。多重线性回归分析显示症状频率评分与年龄、GEFV分级和GERD类型相关(P<0.05),症状严重度评分与年龄、GERD类型相关(P<0.05)。结论:GEFV分级在GERD各亚型中的分布无明显差异,而与GERD症状频率相关。Background：The prevalence of gastroesophageal reflux disease（GERD） has been increasing in our country in recent years,and grading of gastroesophageal flap valve（GEFV） is suggested to play an important role in the evaluation of GERD.Aims：To investigate the distribution of GEFV and its relationship with symptoms in GERD patients.Methods： A total of 343 patients with erosive esophagitis（EE）,483 patients with non-erosive reflux disease（NERD） and 99 patients with Barrett＇s esophagus（BE） from January to December 2010 at Liaocheng People＇s Hospital were enrolled.Endoscopy was performed in all the patients,and Hill＇s classification of GEFV was recorded.The frequency and severity of gastroesophageal reflux symptoms were assessed by GERD symptom assessment scale（GSAS）.The distribution of GEFV and its relationship with frequency and severity score of GERD symptoms were analyzed.Results：Male,older years, overweight and hiatal hernia were the predominant factors in patients with abnormal GEFV.Increased incidence of abnormal GEFV was associated with an increase in Los Angeles classification of EE（P=0.002）,while no significant difference in distribution of GEFV was found among EE,NERD and BE（P=0.612）.The frequency score of GSAS was significantly higher in abnormal GEFV group than in normal GEFV group（P0.05）,but no statistical difference in severity score of GSAS was found between the two groups（P0.05）.Multiple linear regression analysis showed that frequency score of GSAS had correlation with age,GEFV grade and GERD types（P0.05）,while severity score of GSAS was correlated with age and GERD types（P0.05）.Conclusions：No significant difference in distribution of GEFV is seen among EE, NERD and BE,while it is correlated with the frequency score of GERD symptoms.

关 键 词：胃食管阀瓣 胃食管反流 GERD症状评定量表 疝 食管裂孔 

分 类 号：R571[医药卫生—消化系统]