Oligodendrocyte transcription factor 1 overexpression promotes oligodendrocyte transcription factor 2 expression in the brains of neonatal rats exposed to hypoxia  

作　　者：Lijun Yang Hong Cui Aijun Yang Wenxing Jiang 

机构地区：[1]Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China

出　　处：《Neural Regeneration Research》2011年第34期2713-2717,共5页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China, No. 30872778/C1704;the Natural Science Foundation of Beijing, No. 7072023;the Clinical Basic Cooperation Foundation of Capital Medical University, No. 2009jl18;the Clinical Basic Cooperation Foundation of Capital Medical University, No.11JL-L03

摘　　要：To examine the expression profiles of oligodendrocyte transcription factors 1 and 2 （Oligl and Olig2） and the interaction between these two proteins, Oligl was transfected into the lateral ventricles of neonatal rats subjected to hypoxia. Immunohistochemistry demonstrated that Olig2 was expressed throughout the nuclei in the brain, and expression increased at 3 days following hypoxia and was higher than levels at 7 days following Ad5-Oligl transfection. Western blot revealed that Oligl and Olig2 expression increased in Oligl-transfected brain cells 3 days after hypoxia, but Oligl and Olig2 expression decreased at 7 days. These results indicate that Oligl overexpression enhances Olig2 expression in brain tissues of hypoxia rats.To examine the expression profiles of oligodendrocyte transcription factors 1 and 2 （Oligl and Olig2） and the interaction between these two proteins, Oligl was transfected into the lateral ventricles of neonatal rats subjected to hypoxia. Immunohistochemistry demonstrated that Olig2 was expressed throughout the nuclei in the brain, and expression increased at 3 days following hypoxia and was higher than levels at 7 days following Ad5-Oligl transfection. Western blot revealed that Oligl and Olig2 expression increased in Oligl-transfected brain cells 3 days after hypoxia, but Oligl and Olig2 expression decreased at 7 days. These results indicate that Oligl overexpression enhances Olig2 expression in brain tissues of hypoxia rats.

关 键 词：oligodendrocyte transcription factor 1 oligodendrocyte transcription factor 2 HYPOXIA neonatal rat gene transfection neural regeneration 

分 类 号：Q2[生物学—细胞生物学] Q753