Ambiguous nucleus regulates the proliferation and percentage of T lymphocytes in peripheral blood  

作　　者：Wei Wang Wei Chen Yingwu Mei Bin Guo Zhanqing Yang Shoupeng Fu Zhanpeng Yue Juxiong Liu 

机构地区：[1]College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, Jilin Province, China

出　　处：《Neural Regeneration Research》2011年第35期2761-2767,共7页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China,No. 30901057,30871840,31072100;Graduate Innovation Fund of Jilin University,No.20101057

摘　　要：The aim of this study was to examine the immunomodulatory role of the unilateral ambiguous nucleus （Amb）. We performed electrical stimulation of the unilateral Amb, electrical stimulation of the left parietal cortex and the lateral hypothalamus following unilateral Arab lesion, as well as microinjection of acetylcholine chloride and hemicholine-3 into the unilateral Amb, and electrical stimulation of the unilateral Amb after injection of atropine, mecamylamine, propranolol, and phentolamine. Results showed that the number and proliferation of peripheral blood T lymphocytes were increased after electrical stimulation of the unilateral Arab. The cholinergic neurons in the Amb released choline substances to alter cellular immunity, thus confirming that the Amb mediates the neuro-immunomodulatory process.The aim of this study was to examine the immunomodulatory role of the unilateral ambiguous nucleus （Amb）. We performed electrical stimulation of the unilateral Amb, electrical stimulation of the left parietal cortex and the lateral hypothalamus following unilateral Arab lesion, as well as microinjection of acetylcholine chloride and hemicholine-3 into the unilateral Amb, and electrical stimulation of the unilateral Amb after injection of atropine, mecamylamine, propranolol, and phentolamine. Results showed that the number and proliferation of peripheral blood T lymphocytes were increased after electrical stimulation of the unilateral Arab. The cholinergic neurons in the Amb released choline substances to alter cellular immunity, thus confirming that the Amb mediates the neuro-immunomodulatory process.

关 键 词：ambiguous nucleus electrical stimulation T lymphocytes PROLIFERATION neuroimmune regulation parasympathetic nervous system 

分 类 号：S858.292[农业科学—临床兽医学] S853.74[农业科学—兽医学]