Chinese herbal extract dl-3n-butylphthalide A commonly used drug for the treatment of ischemic stroke as a novel therapeutic approach to treat neurodegenerative diseases  

作　　者：Wenfang He Wensheng Zhou Zhiping Hu 

机构地区：[1]Department of Neurology, Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China [2]Department of Neurology, Hunan Province Mawangdui Hospital, Changsha 410016, Hunan Province, China

出　　处：《Neural Regeneration Research》2011年第35期2773-2778,共6页中国神经再生研究（英文版）

基　　金：the Undergraduate Creative Program of Central South University,No. 081053358;the Education Expenditure of Hunan Provincial Finance Department,No. 2010163;the Key Frontier Research Project of Central South University (from 2010 to 2011)

摘　　要：DI-3n-butylphthalide is the active component isolated from the seeds of Apium graveolens Linn. A number of pharmacological and clinical studies have proven that dl-3n-butylphthalide is highly potent and multi-targeted with low toxicity and has a long time-window for the treatment of ischemic cerebrovascular disease. The mechanisms underlying dl-3n-butylphthalide include improving mitochondrial function and microcirculation, inhibiting apoptosis and reducing oxidative stress. Furthermore, dl-3n-butylphthalide may also be promising for the treatment of neurodegenerative diseases, such as Alzheimer＇s disease, vascular dementia and Parkinson＇s disease.DI-3n-butylphthalide is the active component isolated from the seeds of Apium graveolens Linn. A number of pharmacological and clinical studies have proven that dl-3n-butylphthalide is highly potent and multi-targeted with low toxicity and has a long time-window for the treatment of ischemic cerebrovascular disease. The mechanisms underlying dl-3n-butylphthalide include improving mitochondrial function and microcirculation, inhibiting apoptosis and reducing oxidative stress. Furthermore, dl-3n-butylphthalide may also be promising for the treatment of neurodegenerative diseases, such as Alzheimer＇s disease, vascular dementia and Parkinson＇s disease.

关 键 词：3-N-BUTYLPHTHALIDE ischemic stroke neurodegenerative diseases traditional Chinese medicine 

分 类 号：Q255[生物学—细胞生物学] S816.7[农业科学—饲料科学]