3-N-BUTYLPHTHALIDE

作品数：34被引量：421H指数：12
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相关领域：医药卫生更多>>
相关作者：冯亦璞贾敏曹学兵王涛黄金莎更多>>
相关机构：中国医学科学院北京协和医学院华中科技大学中南大学中南大学湘雅三医院更多>>
相关期刊：《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《Neural Regeneration Research》《Chinese Medical Sciences Journal》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划安徽省自然科学基金更多>>
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Dl-3-n-butylphthalide ameliorates diabetic foot ulcer by inhibiting apoptosis and promoting angiogenesis
《World Journal of Diabetes》2025年第4期252-269,共18页Wu-Han Wei Yuan-Ling Bai Dong Zhu Jing-Yu Zhang Qi-Chuan Yin Qiang Li Cai-Qi Shen Pei-Sheng Jin 
Supported by General Project of Xuzhou Science and Technology Bureau,No.KC22070.
BACKGROUND Diabetic foot ulcers(DFU)are estimated to affect about 18.6 million people worldwide annually.The pathogenesis of DFU is complex,and the available drugs are not effective.Dl-3-n-butylphthalide(NBP)is a synt...
关键词：Dl-3-n-butylphthalide Diabetic foot ulcer Network pharmacology ANGIOGENESIS APOPTOSIS 
Dl-3-n-butylphthalide promotes angiogenesis in ischemic stroke mice through upregulating autocrine and paracrine sonic hedgehog被引量：5
《Acta Pharmacologica Sinica》2023年第12期2404-2417,共14页Mei-jie Dai Xing-xing Gui Shu-miao Jia Shu-ting Lv Hao Dou Wei Cui 
the key program of the Educational Department of Liao Ning Province(Nos.LJKZZ20220100).
Dl-3-n-butylphthalide(NBP)is a small-molecule drug used in the treatment of ischemic stroke in China,which is proven to ameliorate the symptoms of ischemic stroke and improve the prognosis of patients.Previous studies...
关键词：ischemic stroke ANGIOGENESIS Dl-3-n-butylphthalide brain ischemia/reperfusion tMCAO model hedgehog signaling pathway 
DI-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis被引量：12
《Neural Regeneration Research》2023年第11期2424-2428,共5页Shuai Li Jingyuan Zhao Yan Xi Jiaqi Ren Yanna Zhu Yan Lu Deshi Dong 
DI-3-n-butylphthalide is used to treat mild and moderate acute ischemic stroke.However,the precise underlying mechanism requires further investigation.In this study,we investigated the molecular mechanism of DI-3-n-bu...
关键词：blood-brain barrier Dl-3-n-butylphthalide hypoxia inducible factor 1α MITOCHONDRIA NEUROPROTECTION oxidative stress reactive oxygen species stroke transcription factor UBIQUITINATION 
A multicenter,randomized,double blind,placebo-controlled clinical trial of DL-3-n-butylphthalide in treatment of amyotrophic lateral sclerosis
《Chinese Medical Journal》2023年第3期354-356,共3页Mingsheng Liu Xiaoli Yao Xusheng Huang Huifang Shang Dongsheng Fan Jia He Liying Cui the Chinese ALS Study Group 
supported by CSPC NBP Pharmaceutical Co.Ltd.
To the Editor:DL-3-n-butylphthalide(NBP)is a synthetic drug based on a component extracted from seeds of Apium graveolens Linn.(Chinese celery).It reportedly has protective effects in amyotrophic lateral sclerosis(ALS...
关键词：clinical amyotrophic protective 
DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease被引量：9
《Neural Regeneration Research》2023年第1期194-199,共6页Chun-Bo Hu Hui Jiang Yin Yang Guo-Hua Wang Qiu-Hong Ji Zhong-Zheng Jia Li-Hua Shen Qian-Qian Luo 
funded by the National Natural Science Foundation of China, No. 81873924 (to QQL), No. 82171190 (to GHW);Nantong Science and Technology Project of China, No. MS22021010 (to LHS);High-level Innovation and Entrepreneurship Talents Introduction Program of Jiangsu Province of China (to QQL)
DL-3-n-butylphthalide(NBP)-a compound isolated from Apium graveolens seeds-is protective against brain ischemia via various mechanisms in humans and has been approved for treatment of acute ischemic stroke.NBP has sho...
关键词：cystine/glutamate antiporter solute carrier family 7 member 11 DL-3-n-butylphthalide ferritin light chain ferroportin 1 ferroptosis glutathione peroxidase 4 oxidative stress iron ROTENONE transferrin receptor 
DL-3-n-butylphthalide improved physical and learning and memory performance of rodents exposed to acute and chronic hypobaric hypoxia被引量：2
《Military Medical Research》2022年第1期1-11,共11页Gang Xu Yi-Kun Shi Bin-Da Sun Lu Liu Guo-Ji E Shu He Jian-Yang Zhang Bao Liu Qiu Hu Jian Chen Yu-Qi Gao Er-Long Zhang 
supported by grants from the National Science and Technology Major Project(2014ZX09J14102-05B and 2018ZX09J18109)。
Background:Studies have revealed the protective effect of DL-3-n-butylphthalide(NBP)against diseases associated with ischemic hypoxia.However,the role of NBP in animals with hypobaric hypoxia has not been elucidated.T...
关键词：DL-3-n-butylphthalide Hypobaric hypoxia Physical function Learning and memory function Oxidative stress Energy metabolism 
DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K/Akt signaling and suppressing oxidative stress被引量：23
《Acta Pharmacologica Sinica》2021年第3期347-360,共14页Bei-ni Wang Cheng-biao Wu Zi-miao Chen Pei-pei Zheng Ya-qian Liu Jun Xiong Jing-yu Xu Pei-feng Li Abdullah Al Mamun Li-bing Ye Zhi-long Zheng Yan-qing Wu Jian Xiao Jian Wang 
supported by the research grants from the National Natural Science Foundation of China(81801233,81870842,81801245,81802238);Natural Science Foundation of Zhejiang Province(LQ18H090011 and LGD21H070001).
DL3-n-Butylphthalide(DLNBP),a small molecular compound extracted from the seeds of Ap/um graveo/ens Linn(Chinese celery),has been shown to exert neuroprotective effects due to its anti-inflammatory,anti-oxidative and ...
关键词：diabetes-associated cognitive decline DL-3-n-butylphthalide cognitive function hippocampus BDNF oxidative stress neuroprotection 
Corrigendum: 3-N-Butylphthalide mitigates high glucose-induced injury to Schwann cells: association with nitrosation and apoptosis被引量：1
《Neural Regeneration Research》2020年第12期2295-2295,共1页
In the article titled"3-N-Butylphthalide mitigates high glucose-induced injury to Schwann cells:association with nitrosation and apoptosis",published on pages 513-518,Issue 3,Volume 14 of Neural Regeneration Research(...
关键词：ANHUI REGENERATION INJURY 
Design and synthesis of the ring-opened derivative of 3-n-butylphthalide-ferulic acid-glucose trihybrids as potential anti-ischemic agents被引量：1
《Chinese Chemical Letters》2020年第7期1881-1886,共6页Jianbing Wu Wei Yin Yinqiu Zhang Hui Ye Yunman Li Jide Tian Zhangjian Huang Yihua Zhang 
the National Natural Science Foundation of China(Nos.81773573,81822041,21977116 and 81673305);National Science&Technology Major Project“Key New Drug Creation and Manufacturing Program”(No.2018ZX09711002006-013);the open project of State Key Laboratory of Natural Medicines(No.SKLNMZZCX201824);State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia Fund(No.SKL-HIDCA-2018-1);Part of the work was supported by Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX18_0795)。
To improve aqueous solubility and anti-ischemic activity of 3-n-butylphthalide(NBP),we designed and synthesized the ring-opened derivative of NBP-ferulic acid-glucose trihybrids(S1-S8).These hybrids inhibited adenosin...
关键词：3-N-BUTYLPHTHALIDE Ferulic acid GLUCOSE HYBRIDS ISCHEMIC Brain-blood barrier 
Effect of dl-3-n-butylphthalide on infarction volume in animal models of ischemic stroke:A meta-analysis
《World Journal of Meta-Analysis》2019年第7期358-372,共15页Di Luan Zheng-Yu Wu Yuan-Xiang Zhang Li-Li Yuan Yang Xu Zhao-Hu Chu Ling-Song Ma Ya-Ping Wang Shou-Cai Zhao 
the National Natural Science Foundation of China,NO.81701161.
BACKGROUND Ischemic stroke is a frequently-occurring disease in the elderly and characterized by high morbidity and mortality.Dl-3-n-butylphthalide(NBP),a synthetic compound based on natural celery seeds,has potential...
关键词：BUTYLPHTHALIDE Animal model ISCHEMIC stroke META-ANALYSIS 
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