Objective: To investigate the therapeutic effect of Ginkgo biloba extract dropping pills combined with butylphthalide capsules on cognitive dysfunction in patients after acute ischemic stroke (AIS) and its impact on s...
supported by the China Society for Drug Regulation(CSDR)Project:exploration of criteria for post-marketing risk assessment of medications using real-world data(DRM2021008);the Special Clinical Pharmacy Program of Shandong Medical Association(YXH2022ZX004)。
BACKGROUND Butylphthalide(NBP)and edaravone(EDV)injection are common acute ischemic stroke medications in China,but there is a lack of large real-world safety studies on them.This study aimed to determine the incidenc...
Objective: to explore the feasibility and effectiveness of butylphthalide sodium chloride combined with argatroban in the clinical treatment of patients with ischemic stroke. Methods: the study was conducted in a retr...
This study was funded by the National Natural Science Foundation of China(No.81971120);the Science and Technology Planning Project of Guangdong Province of China(No 2017A02021520081971120).
Background Cerebral venous disorder may have a harmful effect on ischaemic stroke;however,the underlying mechanism remains to be elucidated.Although Dl-3-n butylphthalide is a multitarget agent for antiischaemic strok...
Objective: to study the curative effect of butylphthalide combined with Xueshuantong on ischemic stroke and its influence on neurological function. Methods: 100 patients with ischemic stroke in our hospital were selec...
Objective: to explore the clinical experience of intravenous thrombolysis of butylphthalide combined with urokinase in the treatment of acute cerebral infarction. Methods: from January 2018 to January 2020 in our hosp...
the National Natural Science Foundation of China(81371355 to YZ,81500989 to YZ,81671191 to YZ and 81820108012 to LL).
Objective To investigate the effects of DL-3-N butylphthalide(NBP)via intranasal delivery after ischaemic stroke in mice.Methods C57BL/6 mice were divided into three groups:sham,stroke with vehicle and stroke with NBP...
Science and Technology Plan of Health and Family Planning Commission of Jiangxi Province(No.20195025);State Administration of Traditional Chinese Medicine Key Discipline of Traditional Chinese Medicine Diagnosis of Traditional Chinese Medicine(No.1242000309)。
Objective:To study the effect of Tongqiao Huoxue Decoction combined with butylphthalide soft capsules on acute ischemic stroke and its effect on serum vascular endothelial growth factor(VEGF).Methods:There are 76 pati...
Key research project of medical science of Hubei province
Objective:To investigate the effects of butylphthalide on reducing neuronal apoptosis in rats with cerebral infarction by inhibiting the JNK/P38 MAPK signaling pathway.Methods:Forty-eight SD male rats were divided int...
the National Natural Science Foundation of China,NO.81701161.
BACKGROUND Ischemic stroke is a frequently-occurring disease in the elderly and characterized by high morbidity and mortality.Dl-3-n-butylphthalide(NBP),a synthetic compound based on natural celery seeds,has potential...