运动对老龄脑缺血再灌注大鼠空间学习记忆能力的影响及其机制  

Effects of Exercise on Learning-memory of Space in Aged Rats after Cerebral Ischemia-reperfusion

作　　者：陈秀恩[1] 郑洁皎[1] 梁贞文[1] 

机构地区：[1]复旦大学附属华东医院,上海市200040

出　　处：《中国康复理论与实践》2012年第1期12-14,共3页Chinese Journal of Rehabilitation Theory and Practice

基　　金：上海市科委基金项目(06JC14027)

摘　　要：目的探讨运动对老龄脑缺血再灌注大鼠空间觉学习记忆的影响及其相关机制。方法 20月龄SD脑缺血再灌注大鼠随机分为试验组和对照组各10只。试验组接受规律的运动训练,对照组在跑台上自由活动。两组在试验1周后分别进行Morris水迷宫测试,检测大鼠海马脑源性神经营养因子(BDNF)mRNA表达。结果与对照组比较,试验组大鼠在第2天的潜伏期缩短(P<0.05),平台周围活动轨迹延长(P<0.05);试验组大鼠海马缺血侧BDNF mRNA表达明显增加(P<0.01)。结论一定强度的规律性运动可提高老龄脑缺血再灌注大鼠空间学习和记忆能力,可能与海马内BDNF mRNA表达增加有关。Objective To study the effects and mechanism of exercise on learning-memory of space and in aged rats after cerebral ischemia-reperfusion.Methods 20 SD rats at the age of 20 months with cerebral ischemia-reperfusion were randomly divided into 2 groups.The experimental group（n=10） received regularly exercise,while the control group（n=10） exercised freely.Morris water maze was tested 1 week after exercise,and the brain-derived neurotrophic factor（BDNF） mRNA expression on the ischemic side of the hippocampus were detected.Results The latency in the 2nd round decreased（P〈0.05） and the path line on the platform increased（P〈0.05） in the experimental group in Morris water maze test（P〈0.05）,while the BDNF mRNA increased（P0.01）,compared with control group.Conclusion Regular exercise can improve space learning-memory ability of cerebral ischemia-reperfusion aged rats,which may associate with increased BDNF mRNA expression in hippocampus.

关 键 词：缺血再灌注 运动 空间学习记忆 大鼠 老龄 

分 类 号：R743.3[医药卫生—神经病学与精神病学]