宫颈癌患者SNSRH和mRH手术前后生存质量的对比研究  

Comparative study of SNSRH and mRH on quality of life of cervical cancer patients before and after surgery

作　　者：陈春林[1] 张福云[1] 刘萍[1] 郭玉[1] 郭红霞[1] 熊樱[1] 刘国炳[1] 

机构地区：[1]南方医科大学南方医院妇产科,广州510515

出　　处：《中国妇产科临床杂志》2012年第1期3-6,共4页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的对比接受了系统保留盆腔自主神经的广泛性子宫切除术(SNSRH)和次广泛性子宫切除术(mRH)的患者手术前后近期的生存质量。方法2007年7月至2009年8月宫颈癌患者64例,进行前瞻性对照研究,其中SNSRH组和mRH组各32例,每例患者手术前、后7～10d、术后1、3、6个月接受EORTCQLQ-C30(v3.0)中文版量表调查。其中有完整的生存质量资料者SNSRH组21例、mRH组22例。结果术前、术后7～10d两组患者的生存质量差异无统计学意义(P>0.05);SNSRH组术后1个月角色功能(RF)下降程度较mRH组低(Z=-4.055,P=0.000),SNSRH组患者术后3个月躯体功能(PF)、角色功能(RF)、社会功能(SF)下降程度均较mRH组低(Z=-2.652、-3.207、-2.501,P=0.008、0.001、0.012);SNSRH组患者术后6个月躯体功能(PF)、角色功能(RF)、社会功能(SF)下降程度较mRH组低(Z=-2.353、-2.294、-2.649、P=0.019、0.022、0.008);而情绪功能(EF)、认知功能(CF)、总体健康状况(QL)两组患者差异无统计学意义(P>0.05)。结论SNSRH组与mRH组两组患者术后近期的生存质量一致性好。Objective To compare the recent mid-term quality of life （QOL） in cervical cancer patients who underwent SNSRH（Systematic nerve-sparing radical hysterectomy） and mRH（Modified Radical Hysterectomy）.Methods Between July 2007 and August 2009,64 cervical cancer patients recruited in this prospective controlled study,among which 32 patinets underwent SNSRH （SNSRH group） and 32 received mRH （mRH group）.All patients were required to fill in EORTC QLQ-C30 （v3.0） Chinese version Scale before surgery,7～10 days,1 month,3 months and 6 months postoperative.21 patients in SNSRH group and 22 in mRH group completed all the scales.Results The quality of life between the two groups pnoperative and 7～10 days postoperatively had no significant difference（p0.05）.The role function （RF） at 1 month postoperative in SNSRH group was significantly lower than that in mRH group （Z =-4.055,P= 0.000）.3 and 6 months postoperative,the decreased levels of physical function （PF）,role function （RF） and social function （SF） in SNSRH group were lower than that in mRH group （Z =-2.652,-3.207,-2.501,P= 0.008,0.001,0.012）,（Z =-2.353,-2.294,-2.649,P=0.019,0.022,0.008）.As for emotional function （EF）,cognitive function （CF） and general health status （QL）,there were no significant difference between the two groups.Conclusion The quality of life in SNSRH group was similar to patinets in mRH group in recent term.

关 键 词：系统保留盆腔自主神经的广泛性子宫切除术 次广泛性子宫切除术 生存质量 EORTCQLQ-C30(V3.0) 

分 类 号：R737.33[医药卫生—肿瘤]