介入化疗联合手术在子宫颈癌治疗中的价值  

Clinical values of surgery plus superselective arterial infusion chemotherapy on treating cervical cancer

作　　者：李环[1] 吴瑞芳[1] 马喆[1] 杨瑞[1] 李瑞珍[1] 楼宝阳[1] 曾荔苹[1] 

机构地区：[1]北京大学深圳医院妇产科,518036

出　　处：《中国妇产科临床杂志》2012年第1期7-10,共4页Chinese Journal of Clinical Obstetrics and Gynecology

摘　　要：目的探讨超选择动脉插管灌注化疗(介入化疗)联合手术在子宫颈癌治疗中的临床应用价值。方法将北京大学深圳医院自2002年4月至2010年1月间收治的ⅠB2～ⅡB期患者共84例作为介入化疗组,采取先介入化疗后手术的方案(8例未行手术),同期ⅠB1～ⅡA期直接手术的对照组82例患者作比较。结果介入化疗有效76例,占90.5%;药物血液系统毒副反应中,白细胞无减少者47例(61.8%),血红蛋白无下降者59例(77.6%);所有患者手术切除顺利,手术后按照相同的标准辅以化放疗。两组患者手术时间、出血量、并发症等比较,差异无统计学意义(P>0.05)。介入化疗组术后患者5年存活率达83.9%%。结论介入化疗联合手术在临床上应用于局部晚期子宫颈癌,安全、有效,为ⅡB期的患者创造手术条件,可提高宫颈癌患者的治疗效果,改善患者的生活质量,具有良好的应用前景。Objective To study the clinical significance of surgery plus superselective arterial infusion chemotherapy in the treatment of cervical carcinoma.Methods 84 cervical cancer patients of stage Ⅰ B2,Ⅱ B and Ⅱ B,who underwent operation after arterial infusion chemotherapy form April 2002 to January of 2010 consisted integrated treatment group（8 cases without surgery）（AIC group）,while 82 patients who only received surgery in the same time were served as control group.Results The effective rate of arterial infusion chemotherapy was 90.5%.The toxicity including 61.8% grade 0 leucopenia and 77.6% grade 0 anemia.After arterial infusion chemotherapy,all the surgery were satisfied.There was no significant difference between the two groups in the operation time,bleeding volume and complications（P0.05）.The 5 years survival rate in AIC group was over 83.9%.Conclusion Surgery plus superselective arterial infusion chemotherapy is safe and effective for treating advanced stage cervical cancer.It can improve the patient＇s life quality and survival rate.

关 键 词：宫颈癌 介入化疗 手术治疗 

分 类 号：R737.33[医药卫生—肿瘤]