低血糖指数膳食替代对2型糖尿病患者的防治作用  

Effects of low-glycemic index meal replacement on management of patients with type 2 diabetes mellitus

作　　者：陈敏[1] 陈艳秋[1] 华莉[1] 宗敏[1] 肖菲[1] 易青[1] 谢华[1] 孙玮[2] 陈爱芳[2] 唐倩如 姜菁静[1] 林轶凡[1] 徐丹凤[1] 孙建琴 

机构地区：[1]复旦大学附属华东医院营养科,上海200040 [2]上海市静安区曹家渡社区卫生服务中心 [3]上海市静安区静安寺社区卫生服务中心

出　　处：《中华内分泌代谢杂志》2012年第1期45-47,共3页Chinese Journal of Endocrinology and Metabolism

基　　金：上海市卫生局科研课题基金（2007168）;上海市科委科研计划课题基金（07ZR14036）

摘　　要：127例社区2型糖尿病患者分为低血糖指数膳食替代组（实验组）和普通膳食组（对照组），试验周期12周。结果显示，实验组空腹血糖、餐后2h血糖、空腹胰岛素、稳态模型评估的胰岛素抵抗指数水平较基线明显下降（P〈0．05或P〈0．01），而HbA1C、血脂水平差异无统计学意义。另外实验组体脂百分数、内脏脂肪面积、腰臀比也较实验前明显下降（均P〈0．01）。实验组12周后其超氧化物歧化酶和谷胱甘肽水平均升高、丙二醛水平降低（均P〈0．01）。上述指标在对照组均无明显变化。实验组与对照组的体重、体重指数和腰围均较实验前下降（P〈0．01），但实验后组间比较差异无统计学意义。A total of 127 type 2 diabetic patients were divided into low glycemic index meal replacements （intervention） group and standard food-based diet （reference） group in an experiment for 12 weeks. The results showed that fasting plasma glucose, postprandial 2 h plasma glucose, fasting insulin, and homeostasis model assessment insulin resistance（HOMA-IR） in the intervention group decreased significantly after 12 weeks trial（ P〈 0. 05 or P〈0. 01 ）. However, there were no significant changes in lipid profile and HbA1c in intervention group. In addition, percentage of body fatty, visceral fatty area, and waist-hip ratio also decreased in intervention group（ all P〈 0. 01 ）. Superoxide dismutase and glutathione levels increased significantly in intervention group by the end of trial （both P〈 0. 01 ）, while malondialdehyde was decreased （P 〈 0.01 ）. There were no significant changes in the aforementioned indices in the reference group. Weight, body mass index, and waist circumferences were decreased in both groups, but without significant difference between the two groups.

关 键 词：低血糖指数 膳食替代 糖尿病 2型 血糖控制 氧化应激 

分 类 号：R587.1[医药卫生—内分泌]