DPPⅣ蛋白和Seprase蛋白在卵巢上皮性癌中的表达及意义  

Expression and Significance of DPPⅣ and Seprase in Human Epithelium Oarian Cancer

作　　者：苑文娜[1] 张梦真[1] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《实用妇产科杂志》2012年第1期57-59,共3页Journal of Practical Obstetrics and Gynecology

基　　金：河南省杰出青年基金资助(编号:104100510007)

摘　　要：目的:探讨二肽基肽酶Ⅳ(DPPⅣ)蛋白和Seprase蛋白在卵巢上皮性癌中的表达及意义。方法:免疫组化法检测DPPⅣ蛋白和Seprase蛋白在128例卵巢上皮性癌、41例卵巢交界性肿瘤和30例卵巢良性肿瘤组织的表达。结果:DPPⅣ蛋白在卵巢上皮性癌组织的阳性表达率为(82.81%),显著高于卵巢交界性肿瘤(56.10%)及卵巢良性肿瘤(16.67%),差异有统计学意义(P<0.05);Seprase蛋白在卵巢上皮性癌组织的阳性表达率为(85.94%),显著高于卵巢交界性肿瘤(60.98%)及卵巢良性肿瘤(20.00%),差异有统计学意义(P<0.05)。两者在卵巢上皮性癌中的表达均与临床分期和淋巴结转移有关。结论:DPPⅣ蛋白和Seprase蛋白参与了卵巢上皮性癌的发生发展,可能成为卵巢上皮性癌的检测指标及基因治疗的潜在靶点。Objective：To determine the expression and significance of DPPⅣ and Seprase protein in human epithelium ovarian cancer.Methods：The expressions of DPPⅣ and seprase were detected by immunohistochemistry in 128 cases of ovarian epithelium cancer,41 cases of ovarian borderline tumor and 30 cases of benign ovarian tumor.Results：The expression rate of DPPⅣ in ovarian cancer was 82.81%,which was much higher than those in borderline tumor（56.10%） and benign tumor（16.67%）,the differences were significant（P〈0.05）.The expression rate of Seprase in ovarian cancer was 85.94%,which was much higher than those in borderline（60.98%）and benign tumor（20.00%）,the differences were significant（P〈0.05）.The expressions of DPPⅣ and Seprase in ovarian cancer were correlated with the clinical stages and lymphatic metastases.Conclusions：DPPⅣ and Seprase protein involve in the carcinogenesis and development of ovarian cancer,may be the diagnostic marker and potential therapeutic target.

关 键 词：卵巢上皮性癌 二肽基肽酶Ⅳ SEPRASE 免疫组化 

分 类 号：R737.31[医药卫生—肿瘤]