银屑病转基因动物模型研究进展  

Study on transgenic animal models of psoriasis

作　　者：王娅[1] 朱健平[1] 赖奇伟[1] 

机构地区：[1]广东医学院药理学教研室,广东湛江524023

出　　处：《中国药理学通报》2012年第1期13-16,共4页Chinese Pharmacological Bulletin

基　　金：东莞市高等院校科研机构研发项目(No 2008108101037)

摘　　要：银屑病是一种受多基因遗传因素影响和多种环境因素诱导所产生的慢性炎症性皮肤疾病。为了阐明银屑病复杂的发病机制和开展药物治疗学的研究,建立一个理想的动物模型是关键,近年来随着转基因技术的发展,构建各种银屑病相关的转基因动物模型成为热点。该文就银屑病转基因动物模型的研究现状作一综述。Psoriasis is a chronic inflammatory dermatosis induced by polygenic inheritance and multiple environmental factors.The key to study the pathogenesis and pharmacodynamics of psoriasis is to establish some ideal animal models.As the transgenic technology is developing,establishing transgenic animal models related to psoriasis has become the researching focus.The recent findings about transgenic animal models of psoriasis are summarized and discussed in this review.

关 键 词：银屑病 转基因 动物模型 皮肤病 易感基因 综述 

分 类 号：R-05[医药卫生] R363-332