年龄对帕金森病患者运动功能障碍的影响  

Influence of aging on the severity of different motor signs in Parkinson disease

作　　者：叶瑞东[1] 雷辉[2] 屈秋民[3] 王新来[2] 李会琪 宋春霞[5] 林海 刘健 赵钢[1] 

机构地区：[1]第四军医大学西京医院神经内科,西安710032 [2]西安市中心医院神经内科 [3]西安交通大学第一附属医院神经内科 [4]西安市西电集团医院神经内科 [5]西安医学院附属医院神经内科 [6]西安市中医医院神经内科 [7]西安市电力医院神经内科

出　　处：《陕西医学杂志》2011年第12期1624-1627,共4页Shaanxi Medical Journal

摘　　要：目的:探讨帕金森病(PD)患者运动功能障碍的影响因素。方法:93例PD患者接受了调查。采用PD统一评分量表(UPDRS)评估患者各项运动功能障碍如震颤、肌强直、动作缓慢、面部表情、语言表达和中轴(步态和姿势)损伤。分析患者的性别、年龄、发病年龄、病程、受教育情况、治疗情况与UPDRS评分的相关性。结果:患者的UPDRS评分与认知水平和年龄显著相关;震颤与病程相关。回归分析显示患者年龄是影响UPDRS评分及中轴损伤的主要因素。结论:PD患者中轴损伤症状可能源于正常衰老和疾病本身共同作用的结果,在治疗中应重视老年患者的中轴运动损伤症状。Objective： To investigate the contribution of aging to the severity of different motor signs of Parkinson disease（PD）.Methods： 93 PD patients were evaluated using unified PD rating scale（UPDRS）.The total UPDRS motor score was divided into 6 motor domains（tremor,rigidity,bradykinesia,facial expression,speech,and axial impairment）.We assessed the correlation of each motor score with sex,years of education,age at the examination,duration of disease,age at the onset,and medication.Results： The total UPDRS motor score was correlated with cognitive level and age.Tremor was correlated with the duration of disease.Linear regression analysis showed that age was the most significant influential factor for the total motor score and axial impairment.Conclusion： Axial（gait and postural） impairment in PD may result from the combined effect of the disease and the aging process.More attention should be paid to the axial impairment,especially in the aged PD patients.

关 键 词：帕金森病 运动障碍 年龄因素 

分 类 号：R742[医药卫生—神经病学与精神病学]