胃蛋白酶原在健康检查胃部疾病筛查中的价值  

Clinical Value of Pepsinogen in Gastric Diseases Screening of Health Examination

作　　者：华嘉临[1] 张艺[2] 黄飚[2] 

机构地区：[1]江苏省无锡市人民医院体检中心,214023 [2]江苏省原子医学研究所

出　　处：《职业与健康》2011年第24期2945-2946,共2页Occupation and Health

基　　金：江苏省卫生厅重点科研项目(项目编号:H200856);江苏省社会发展基金资助项目(项目编号:BE2009631)

摘　　要：目的检测胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)对胃部疾病检出的价值。探讨血清胃蛋白酶原检测在健康检查中筛查胃部疾病的应用价值。方法采用PGⅠ、PGⅡ时间分辨荧光试剂盒,对718例胃部疾病患者及2 532例健康检查人群血清测定PGⅠ、PGⅡ含量和PGⅠ/PGⅡ比值。结果胃蛋白酶原对慢性浅表性胃炎、慢性萎缩性胃炎、胃癌、胃溃疡的阳性率分别为56.1%、73.8%、40.7%、41.7%。在体检人群中约13%的人血清PGⅠ或PGⅡ异常。结论血清胃蛋白酶原是胃病疾病的良好指标,在体检应用方面有较好的价值。[Objective]To estimate the diagnostic value of pepsinogen Ⅰ（PGⅠ） and pepsinogen Ⅱ（PGⅡ） in detection of gastric diseases,discuss the application value of serum pepsinogen（PG） test in gastric diseases screening of health examination. [Methods]By using time-resolved fluorescence immunoassay（TRFIA）,the levels of serum PGⅠand PGⅡ,and PG I/PG II ratio were examined in 718 patients with gastric diseases and 2 532 healthy controls. [Results]The positive rates of serum PG test was 56.1%,73.8%,40.7% and 41.7% in chronic superficial gastritis,chronic atrophic gastritis,gastric cancer and gastric ulcer,respectively.Among people who received health examination,13% had abnormal levels of serum PG Ⅰ or PG Ⅱ. [Conclusion]Serum PG is a reliable biochemical marker for the diagnosis of gastric diseases,and it has significant practical value on disease screening of health examination.

关 键 词：胃病 胃蛋白酶原 健康检查 筛查 

分 类 号：R573[医药卫生—消化系统]