甲胎蛋白、铜蓝蛋白和触珠蛋白联合诊断原发性肝癌评价  

Diagnostic evaluation of hepatocellular carcinoma by combined determination of alpha-fetoprotein,ceruloplasmin and Haptoglobin

作　　者：高国生[1] 冯家飞[1] 丁世雄[1] 

机构地区：[1]浙江省宁波市第二医院检验科,浙江宁波315010

出　　处：《中国卫生检验杂志》2011年第12期2833-2834,2842,共3页Chinese Journal of Health Laboratory Technology

基　　金：宁波市自然基金资助(2010A610056)

摘　　要：目的:探讨血清甲胎蛋白、铜蓝蛋白和触珠蛋白在检测原发性肝癌诊断中的价值。方法:对40例健康献血员,66例慢性乙型肝炎、69例乙肝肝硬化及60例原发性肝癌患者分别采用免疫透射比浊法和微粒子酶免疫分析技术检测血清甲胎蛋白、铜蓝蛋白和触珠蛋白含量及作统计学分析。结果:原发性肝癌患者血清甲胎蛋白和铜蓝蛋白水平均高于正常对照组,触珠蛋白水平高于乙型肝炎和肝硬化组。通过logistic回归模型构建的联合预测因子显著提高了原发性肝癌的诊断效能。结论:甲胎蛋白、铜蓝蛋白和触珠蛋白联合检测,对HBSAg阳性原发性肝癌的早期诊断有重要价值。Objective：To evaluate the clinical value in diagnosis of hepatocellular carcinom（HCC） by combined determination of alpha-fetoprotein（AFP）,ceruloplasmin（Cp） and haptoglobin（Hp）.Methods： The serum AFP,Cp and Hp were detected by immune nephelometry and microparticle chemiluminescent immunoassay in 40 healthy adults,66 patients with chronic hepatitis B,69 patients with liver cirrhosis and 60 patients with hepatocellular carcinoma.Then a statistical analysis was made on these results.Results： In the patients with HCC,the serum levels of AFP and Cp were higher than those in normal control group,and the serum level of Hp was higher than in the patients with chronic hepatitis B and liver cirrhosis.Combining predictors of probabilities established by the logistic model can significantly improve the diagnosis efficiency of HCC.Conclusion： Combined determination of serum AFP,Cp and Hp is important for the early diagnosis of hepatitis B virus-associated HCC.

关 键 词：原发性肝癌 乙型肝炎病毒 甲胎蛋白 铜蓝蛋白 触珠蛋白 

分 类 号：R735.7[医药卫生—肿瘤]