吉西他滨固定剂量率静滴联合奥沙利铂治疗晚期胆道癌的临床研究  

A Clinical Study of Fixed-dose Rate Gemcitabine Infusion Combined with Oxaliplatin in the Treatment for Patients with Advanced Biliary Tract Cancer

作　　者：郑维锷[1] 张武[1] 原少斐[1] 陈华[1] 吴丽丽[1] 陈文俊[1] 

机构地区：[1]温州医学院附属第三医院,浙江瑞安325200

出　　处：《肿瘤学杂志》2011年第11期854-856,共3页Journal of Chinese Oncology

摘　　要：[目的]评价吉西他滨固定剂量率静滴联合奥沙利铂(GEMOX方案)治疗晚期胆道癌的疗效和毒副作用。[方法]47例晚期胆道癌患者均接受吉西他滨1 000mg/m2,10mg/(m2.min)静滴,d1、8;奥沙利铂130mg/m2,静脉滴注2h,d1;每3周重复。至少化疗3个周期。[结果]47例患者均可评价疗效,无完全缓解病例,部分缓解9例(19.2%),稳定22例(46.8%),进展16例(34.0%),总有效率(CR+PR)为19.2%(9/47)。中位无进展生存期(PFS)4.7个月,中位总生存期(OS)9.3个月。主要毒副反应为中性粒细胞减少、血小板减少,恶心、呕吐,肝肾和外周神经毒性等。[结论]吉西他滨固定剂量率静滴联合奥沙利铂治疗晚期胆道癌有效,但其血液学毒性需引起重视。[Purpose] To investigate the efficiency and toxicity of fixed-dose rate gemcitabine combined with oxaliplatin in the treatment for patients with advanced biliary tract cancer（BTC）.[Methods] Forty-seven cases with advanced BTC received the combination of gemcitabine and oxaliplatin（GEMOX regimen,gemcitabine at the dose of 1 000mg/m 2,10mg/（m 2.min） intravenous infusion,d 1,8;oxaliplatin at 130mg/m 2 intravenous drip 2h on d 1.Every 3 weeks as a cycle,and the patients received at least 3 cycles.[Results] All of 47 patients were evaluable for efficacy,none of them achieved complete remission,9 cases（19.2%）,partial remission;22 cases（46.8%）,stable disease;and 16 cases（34.0%）,progressive disease.The overall response rate was 19.2%（9/47）.The median progression-free survival（PFS） was 4.7 months and the median overall survival（OS） was 9.3 months.The main toxicity was neutropenia,thrombocytopenia,nausea and vomiting,liver,renal and peripheral nerve toxicity.[Conclusion] The fixed-dose rate gemcitabine infusion combined with oxaliplatin for patients with advanced biliary tract cancer is effective,but need pay attention to the hematologic toxicity.

关 键 词：胆道肿瘤 吉西他滨 固定剂量率 奥沙利铂 

分 类 号：R735.8[医药卫生—肿瘤]