吸附澄清剂在HL颗粒中的应用  

The Applications of Clarifying Agent in HL Granules

作　　者：刘丽波[1] 洪燕 王芳[3] 

机构地区：[1]南方医科大学附属小榄人民医院药剂科,中山528415 [2]江西省崇仁县人民医院妇产科,崇仁344200 [3]江西中医学院药学院,南昌330004

出　　处：《江西中医学院学报》2011年第5期43-45,共3页Journal of Jiangxi College of Traditional Chinese Medicine

摘　　要：目的:考察吸附澄清剂在HL颗粒除杂工艺中的应用。方法:以黄芪甲苷的含量、干膏得率为指标,比较了乙醇沉淀与加澄清剂的除杂效果;并采用单因素实验优选了ZTC1+1-Ⅱ型吸附澄清剂除杂的工艺参数,包括ZTC1+1-Ⅱ型吸附澄清剂的加入量、加入顺序、药液浓度、搅拌速度等。结果:ZTC1+1-Ⅱ型吸附澄清剂处理对黄芪甲苷含量影响较小,且能明显降低出膏率,研究所得除杂工艺为:取提取液浓缩至药材重(g)与提取液体积(ml)为1:5时,先加入澄清剂B组分,后加入A组分,搅拌速度100～150 r/min。结论:澄清剂法比水醇法工艺简单,生产周期短,减少乙醇用量,节省能源,以ZTC1+1-Ⅱ型吸附澄清剂除杂能较好的保留黄芪甲苷,而且除杂效果明显。Objective： To apply ZTC1＋1-Ⅱ clarifying agent for the removal of extraneous materials in HL granules.Method： Taking the content of astragaloside IV and extract yield as the main index,we used single factor design method for investigating ZTC1＋1-Ⅱ clarifying agent of the relevant factors.The optimum combination of factors and alcohol precipitation methods were compared.Result： The effect of ZTC1＋1-Ⅱ clarifying agent of impurity was better than alcohol precipitation.Conclusion： ZTC1＋1-Ⅱ clarifying agent is a better way to impurity.The method is convenient,economical and safe with the effect of imparity removal.

关 键 词：澄清剂 黄芪甲苷 含量测定 HPLC-ELSD 

分 类 号：R944.27[医药卫生—药剂学]