阿司匹林作用机制的进展与药学监护  

Progress in the Study of Mechanism of Action of Aspirin and Pharmaceutical Care

作　　者：王建民[1] 张雪梅[1] 付燕霞[1] 

机构地区：[1]北京军区总医院药剂科,北京100700

出　　处：《中国医院用药评价与分析》2011年第12期1150-1152,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:围绕血栓形成机制,非甾体抗炎药阿司匹林抑制环氧酶而成为对抗血小板的"基石",本文总结阿司匹林的临床应用评价和监护要点,以供临床合理用药参考。方法:查阅近年来国内、外相关文献,进行归纳和分析。结果与结论:在大量的临床研究中,阿司匹林显示了良好效果,但其所致出血和消化道溃疡的风险较大,使得药学监护十分重要。OBJECTIVE：With regard to the mechanism of thrombogenesis,the inhibitory action of the non-steroidal anti-inflammatory drug（NSAID） Aspirin on epoxidase has become the ＂cornerstone＂ against platelet.This paper aims to summarize the clinical application evaluation of Aspirin and key points in pharmaceutical care in using Aspirin to provide references for clinical rational drug use.METHODS： The pertinent literature both at home and abroad in recent years were retrieved and subjected to a systematic meta-analysis.RESULTS CONCLUSION： Numerous clinical trials have demonstrated the remarkable efficacy of Aspirin;however,its use involves great risks of bleeding and digestive ulcer,thus the pharmaceutical care for patients treated with Aspirin is of utmost importance.

关 键 词：阿司匹林 抗血小板 凝血因子 药学监护 合理用药 

分 类 号：R971.1[医药卫生—药品]